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当前位置: 首页 > 文章 > 槲寄生在荷瘤小鼠体内的抗肿瘤作用研究 畜牧与饲料科学 2009,30 (6) 15-16
Position: Home > Articles > Antitumor Effect of Mistletoe on Mice Sarcoma in Vivo Animal Husbandry and Feed Science 2009,30 (6) 15-16

槲寄生在荷瘤小鼠体内的抗肿瘤作用研究

作  者：
LI Ya-xion
单  位：
Department of Hematology,the 202th Hospital of Shenyang Military,Shenyang 110003,China
关键词：
mice;sarcoma;antitumor;inhibitory ratio;injected;treate
摘  要：
为了探讨槲寄生在荷瘤小鼠体内的抗肿瘤作用,将槲寄生提取物1.65～15mg/(kg·d)经皮下分别注射于荷肉瘤S180的实体瘤和腹水瘤小鼠体内,连续注射9d后,分别对其肿瘤重量、抑瘤率、脾有核细胞数、脾指数、生存期以及肿瘤组织等病理变化进行观测。试验结果表明,槲寄生对体内肿瘤生长的抑制率为14.7%～28.3%,经其治疗后,小鼠的存活时间及脾指数均明显高于对照组(P<0.01),且其瘤组织中为较致密的结缔组织,对照为疏松的结缔组织。槲寄生在荷瘤小鼠体内有明显的抗肿瘤作用,对脾脏的保护功能可能与其抗瘤机制有关。
译  名：
Antitumor Effect of Mistletoe on Mice Sarcoma in Vivo
作  者：
LI Xin1,LI Ya-xiong2(1.Department of Physiology,School of Life Sciences and Biopharmaceutical Sciences,Shenyang Pharmacentical University,Shenyang 110016,China;2.Department of Hematology,the 202th Hospital of Shenyang Military,Shenyang 110003,China)
关键词：
Mistletoe;anti-tumor effect;sarcoma S180 cells;mice sarcoma
摘  要：
The aim was to explore the antitumor effect of mistletoee extract(ME) on resisting tumor in mice with sarcoma S180 in the study.Sarcoma180 mice bearing in solid form and ascites form respectively was injected into sarcoma with the dosage of 1.65 mg/(kg·d) to 15 mg/(kg·d) of ME for 9 days continuously,then these indexes respectively was examined including tumor weight,inhibitory ratio of tumor growth,number of spleen nucleated cells,spleen index(SI),survival time and histopathology of tumor tissues and several viscera.Inhibitory ratio of tumor growth reached 14.7 % to 28.3 % after injected,and the treated in survival time and SI both were higher than that of the control(P<0.01),in histology,the treated tumors was encapsulated in firm connective tissue,while the control was loosely structured connective tissue.Seen from the result,there is an anti-tumor effect of the mistletoe in vivo,and it may be associated with the increase in protecting spleen function.

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