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Position: Home > Articles > Review on HIF-1α Gene in Hypoxia Adaptation of Tibetan Chicken China Animal Husbandry & Veterinary Medicine 2011,38 (12) 86-89

低氧诱导因子-1α基因在藏鸡低氧适应机制中的研究进展

作  者:
杨云周;张吉斌;方美英
单  位:
中国农业大学动物科技学院
关键词:
HIF-1α;低氧;适应;高原;藏鸡
摘  要:
作为调控氧稳态的主要转录因子,低氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)对维持机体氧平衡和适应低氧环境具有关键作用。常氧环境条件下,HIF-1α蛋白持续合成并被不断降解;低氧环境条件下,HIF-1α蛋白降解受阻并与HIF-1β转录因子二聚化形成HIF-1作用于其靶基因发挥低氧调节作用,维持机体在低氧条件下的生存。世代生活在高原低氧环境中的藏鸡,形成了完整的适应低氧环境遗传机制。作者将系统介绍HIF-1α基因结构、编码产物特征及其低氧适应作用机理,并探讨藏鸡HIF-1α基因参与其低氧适应的遗传机制的研究进展。
译  名:
Review on HIF-1α Gene in Hypoxia Adaptation of Tibetan Chicken
作  者:
YANG Yun-zhou,ZHANG Ji-bin,FANG Mei-ying(College of Animal Science and Technology,China Agricultural University,Beijing 100193,China)
关键词:
HIF-1α;hypoxia;adaptation;highland;Tibet chicken
摘  要:
Hypoxia inducible factor-1α(HIF-1α) is a transcriptional factor that plays an essential role both in organisms'adaptation to hypoxia and maintenance of oxygen homeostasis.Under normoxia,synthesized HIF-1α protein protein will be degraded immediately;under hypoxia,stabilized HIF-1α protein will dimerize with HIF-1β to form HIF-1 which could regulate oxygen homeostasis.Tibetan chicken have been living in high altitude and low-O2 tension environment for many centuries,and has special molecular pathways for adaptation to hypoxia.This review will summary the genetic structure of HIF-1α gene and its role in hypoxia adaptation of Tibetan chicken.

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