单 位：
农业部农药检定所;中国农业大学;全国农业技术推广中心
关键词：
杀鼠迷;布氏田鼠;急性毒力;致死中量;应用
摘 要：
初步研究了杀鼠迷对布氏田鼠(Lasiopodomys brandtii)的急性毒力,结合实验室无选择给药对其药效应用进行了初步评价。依据孙氏改良寇氏综合计算法,以测致死中量(LD50)的方式,配制梯度浓度杀鼠迷药液对以灌胃法试鼠给药测定单次给药和4d四次给药时LD50值;同时配制0.0375%和0.1%两个质量分数的杀鼠迷毒饵对两组试鼠无选择连续给药5d,评价药效。结果表明,1次灌胃时杀鼠迷药效不稳定而且毒力较低;4d四次给药LD50值为9.739mg/kg,标准误为0.079,其95%平均可信限为(9.739±3.443)mg/kg;摄食试验中,0.0375%质量分数组摄食系数为0.566,灭杀率为30%,0.1%质量分数组摄食系数为0.563,灭杀率为80%。按毒力分级标准,杀鼠迷对布氏田鼠单次给药毒力为弱毒或者更低,4d四次给药毒力达到剧毒水平,有实际应用的潜力,但是急性毒力在个体间差异较大,并且药物适口性低,建议在实际鼠防工作中应用时先作预试验以检验药效。
译 名：
Primary Study on Acute Virulence and Application of Coumaterralyl to the Brandti's Voles
作 者：
GAO Zhi-xiang1, WU Xin-ping2, JI Li-li2, GUO Yong-wang3, SHI Da-zhao1 (1.China Agricultural University, Beijing 100094, China; 2.Institute for the Control of Agrochemicals, Ministry of Agriculture, P. R. China, Beijing 100026, China; 3.National Agro-tech Extensions and Service Center, Beijing 100026, China)
关键词：
coumateteralyl; brandti's voles; virulence; LD50; application
摘 要：
To test the acute virulence of Coumaterralyl against Brandti's voles(Lasiopodomys brandtii)and to deter- mine the its feasibility of application in practice, the Brandti's voles were treated the toxicant in different consistencies with gavage infusing in stomach according as the Sun Improved K er's Integrated method in laboratory; At the same time the feeding test which two groups of animals included 10 each were given the bait containing 0.0375% and 0.1% toxicant respective in no-choice way was carried out. The result showed that the acute toxicity of once toxicant given way is low and its effect is unstable; The LD50 of 4 times/4 days toxicant given way was 9.739 mg/kg and the standard error was 0.079, the confidence limit on 95% was (9.739±3.443) mg/kg; In the feeding test, the tasting acceptance of 0.0375% bait was low and the chosen coefficient is 0.566, the lethal rate was 30%, when administered with 0.1% bait the acceptance was low too and the coefficient is 0.563, the lethal rate was 80%. These revealed that the acute virulence of Coumaterralyl to Brandti's voles of once toxicant given way was low or even less, when came to 4 times/ 4 days way it was the virulent level by the graded standard of toxicant against mice which presumed its potential of use in controlling job, but the toxicity has diversity in individuals and the tasting acceptance was not good. It suggested that pre-test be carried out to inspect the effect to certain bandicoot before its chosen being used in practical.
