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当前位置: 首页 > 文章 > 基于高通量测序和小分子核苷类似物诊断与治疗猫传染性腹膜炎病例转归 畜牧兽医学报 2022,53 (1) 200-208
Position: Home > Articles > A Case Report of Feline Infectious Peritonitis based on High-throughput Sequencing Diagnosis and Small-molecule Nucleoside Analogues Treatment Chinese Journal of Animal and Veterinary Sciences 2022,53 (1) 200-208

基于高通量测序和小分子核苷类似物诊断与治疗猫传染性腹膜炎病例转归

作  者：
李笨;郭富强;王伟伟;金宁一;金秋实;米志强;李昌;王茂鹏
单  位：
瑞鹏宠物医院;中国农业科学院长春兽医研究所;牡丹江心血管病医院影像介入诊疗中心;温州大学病毒学研究所;军事医学研究院微生物流行病研究所
关键词：
猫传染性腹膜炎;猫冠状病毒;高通量测序技术;GS-441524
摘  要：
猫传染性腹膜炎(简称猫传腹)是一类由冠状病毒引起、以严重腹腔炎症为特征的高致死性传染病,然而对其病原的诊断尚无公认的标准方法,且无有效的治疗手段可应用于兽医临床。因此,本研究通过描述一例猫传染性腹膜炎病例诊治过程,探索针对该病的合理诊疗手段。本研究利用高通量测序技术,综合临床症状、生化分析、血常规等检测方法,实现对该病例的诊断,基于白/球蛋白比、fSAA等临床指标评估抗病毒药物GS-441524治疗效果,监控转归进程。结果表明高通量测序技术可应用于猫传腹的诊断过程,经高剂量药物治疗后临床症状明显改善,8周白/球蛋白比、fSAA两项特征指标恢复正常,10周符合出院标准,16周复查未见疾病复发迹象。此病例的成功治疗证明高通量测序技术在兽医临床诊断的应用价值和GS-441524药物对危重病例治疗的有效性,血清白/球蛋白比(≥0.6)和fSAA(<5μg·mL~(-1))可作为临床指标评估治疗效果。
译  名：
A Case Report of Feline Infectious Peritonitis based on High-throughput Sequencing Diagnosis and Small-molecule Nucleoside Analogues Treatment
作  者：
LI Ben;GUO Fuqiang;WANG Weiwei;JIN Ningyi;JIN Qiushi;MI Zhiqiang;LI Chang;WANG Maopeng;Institute of Virology, Wenzhou University;Ruipeng Pet Hospital;Changchun Veterinary Research Institute,Chinese Academy of Agricultural Sciences;Centre of Imaging Diagnosis and Interventional Treatment, Mudanjiang Cardiovascular Disease Hospital of Heilongjiang Province;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology;
关键词：
feline infectious peritonitis;;feline coronavirus;;high-throughput sequencing technology;;GS-441524
摘  要：
Feline infectious peritonitis(FIP) is a highly lethal infectious disease caused by coronavirus and characterized by severe abdominal cavity inflammation. However, there is no approved standard method for the diagnosis or treatment of pathogen. Therefore, this study describes the diagnosis and treatment process from a case report of feline infectious peritonitis and explores reasonable diagnosis and treatment methods for the disease. High-throughput sequencing technology, clinical symptoms, biochemical analysis, blood routine and etc. were comprehensively used to diagnose this case, to evaluate the treatment effect of the antiviral drug GS-441524 with albumin/globulin ratio and fSAA level, and to monitore the sequelae. Results showed that high-throughput sequencing technology can be applied to the diagnosis of FIP. After high-dose drug treatment, the clinical symptoms were significantly improved, the albumin/globulin ratio and fSAA were restored to normal at 8 weeks, and the discharge standards were met at 10 weeks. No signs of disease recurrence were found during the 16-week review. The successful treatment of this case proves the potential of high-throughput sequencing technology in veterinary clinical diagnosis, and the effectiveness of GS-441524 in the treatment of critical cases. The serum albumin/globulin ratio(≥0.6) and fSAA(<5 μg·mL~(-1)) can be a clinical indicator to evaluate the therapeutic effect.

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