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Position: Home > Articles > The Polymorphism of Bovine PRNP and Resistance Grass-Feeding Livestock 2008 (2) 12-15

牛朊蛋白基因多样性与抗病性研究进展

作  者:
管峰;潘磊;石国庆;杨利国
单  位:
华中农业大学动物科技学院;新疆兵团绵羊繁育生物技术重点实验室;中国计量学院生命科学学院
关键词:
PrP;可传播海绵状脑病(TSE);PRNP多样性;抗病性/易感性
摘  要:
朊蛋白(Prion protein,PrP)是近来证明的可传播性海绵状脑病(TSE)的根源,牛朊蛋白基因(PRNP)多样性与抗病性/易感性存在相关关系。本文就朊蛋白的生物学特征和牛PRNP多样性与抗病性/易感性的关系进行简要综述,旨在为牛的抗病性评价和抗病育种提供理论参考。
译  名:
The Polymorphism of Bovine PRNP and Resistance
作  者:
GUAN Feng1, PAN Lei1, SHI Guo-Qing2, YANG Li-Guo3 (1. College of life sciences, China Jiliang University, Hangzhou 310018, China; 2. The Key Sheep Breeding and Reproduction Biotechnology Laboratory , Xinjiang Production and Construction Group, Shihezi, 832000 China; 3. College of Animal Science, Huazhong Agricultural University, Wuhan 430070, China)
关键词:
Prion protein; TSE; PRNP polymorphisms; Susceptibility/Resistance
摘  要:
Prion protein (PrP) was the resource of prion diseases that had been proved in recent years. Prion protein gene (PRNP) polymorphisms had a relationship with susceptibility or resistance of these diseases. In this article, the characters and relationship of bovine PRNP polymorphisms on susceptibility or resistance were reviewed, the aim is to provide theory reference for bovine breeding and further study of prion diseases.

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