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Position: Home > Articles > Progresses of basic research on L-valine biosynthesis and the breeding of L-valine hyper-producer Science and Technology of Food Industry 2010,31 (10) 408-412

L-缬氨酸生物合成的基础研究和菌种选育的进展

作  者:
刘焕民;张伟国
单  位:
江南大学生物工程学院
关键词:
L-缬氨酸;酶;调控;育种
摘  要:
L-缬氨酸在医药、食品及饲料领域中有着广泛的用途。L-缬氨酸合成途径的调节有很多特点:比如该途径与L-异亮氨酸合成途径有多步反应共用同一种酶;该途径与另外两支链氨基酸合成途径是平行关系;该途径涉及的关键酶的活性和基因的表达都存在多价调节机制。本文概述了L-缬氨酸的生物合成途径关键酶的性质和基因表达的特点的研究进展;并结合上述机理阐述了国内外L-缬氨酸生产菌的传统的诱变育种方法和兴起的基因工程育种方法的发展现状。
译  名:
Progresses of basic research on L-valine biosynthesis and the breeding of L-valine hyper-producer
作  者:
LIU Huan-min,ZHANG Wei-guo (School of Biotechnology,Jiangnan University,Wuxi 214122,China)
关键词:
L-valine;enzyme;regulation;breeding
摘  要:
L-valine was widely used in making medicine,food industry and feed ingredient. Regulation of the biosynthesis pathways of L-valine has many features,such as homologous reactions catalyzed by a single enzyme,parallel pathways,and multivalent regulation of both gene expression and enzyme activity. This paper summarized progresses of the property of the key enzymes and the regulation of its genes expression in the L-valine biosythesis pathways,and described the breeding of L-valine hyper-producer in our nation and other countries.

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