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Position: Home > Articles > Advances in Research on Bioactivity and Biotransformation of Gypenoside FOOD SCIENCE 2018 (13) 324-333

绞股蓝皂苷生物转化与活性的研究进展

作  者：
郑溢;李旎;郑志忠;陈良华;童庆宣;明艳林;林河通
单  位：
厦门华侨亚热带植物引种园厦门市植物引种检疫与植物源产物重点实验室;福建农林大学食品科学学院;福建省亚热带植物研究所福建省亚热带植物生理生化重点实验室
关键词：
绞股蓝;绞股蓝皂苷;生物转化;生物活性
摘  要：
绞股蓝为葫芦科绞股蓝属植物,含皂苷、黄酮、多糖等多种成分,具有防衰老、降血糖、降血脂、抑制肿瘤等多种生物活性。绞股蓝皂苷是绞股蓝的主要活性成分之一,因其具有与人参皂苷相同的四环三萜达玛烷型母核结构而备受关注。近年来,通过生物转化对绞股蓝皂苷上的糖基进行改造以制备活性较高的次生皂苷成为研究热点,并出现大量相关的研究报道,但鲜有较为系统的文献整理。鉴于此,本文综述了绞股蓝皂苷的结构与类别、绞股蓝皂苷与人参皂苷的异同、绞股蓝皂苷的生物转化及其生物活性的研究进展,并就绞股蓝皂苷未来的研究方向提出建议,以期为绞股蓝皂苷的进一步研究提供思路。
译  名：
Advances in Research on Bioactivity and Biotransformation of Gypenoside
作  者：
ZHENG Yi;LI Ni;ZHENG Zhizhong;CHEN Lianghua;TONG Qingxuan;MING Yanlin;LIN Hetong;College of Food Science, Fujian Agriculture and Forestry University;Xiamen Key Laboratory of Plant Introduction and Quarantine and Plant Derived Products, Xiamen Overseas Chinese Subtropical Plant Introduction Garden;Fujian Key Laboratory of Subtropical Plant Physiology and Biochemistry,Fujian Institute of Subtropical Botany;
单  位：
ZHENG Yi%LI Ni%ZHENG Zhizhong%CHEN Lianghua%TONG Qingxuan%MING Yanlin%LIN Hetong%College of Food Science, Fujian Agriculture and Forestry University%Xiamen Key Laboratory of Plant Introduction and Quarantine and Plant Derived Products, Xiamen Overseas Chinese Subtropical Plant Introduction Garden%Fujian Key Laboratory of Subtropical Plant Physiology and Biochemistry,Fujian Institute of Subtropical Botany
关键词：
Gynostemma pentaphyllum;;gypenoside;;biotransformation;;bioactivities
摘  要：
Gynostemma pentaphyllum, a plant of the Cucurbitaceae family, contains saponins, flavonoids, polysaccharides and other bioactive ingredients and has many bioactivities such as inhibiting tumor, reducing blood fat and blood sugar, antiaging, and protecting cells. Gypenoside, a major active ingredient in G. pentaphyllum, has arisen much attention in recent years, because it contains the same mother nucleus of dammarane-type tetracyclic triterpenoids as ginsenoside. In recent years, modification of the glycosidic moiety of gypenoside by bioconversion for derivatives with improved activity has become a research hotspot, and abundant studies on this topic exist in the literature. However, a systematic review is still lacking. In this context, this paper reviews recent advances in research on the structure and classification of gypenosides, the difference and similarity between gypenosides and ginsenosides, and the biotransformation and bioactivity of gypenosides. Finally, directions for future research are put forward. Hopefully, this review will provide insights for gypenosides biotransformation in vitro.

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