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Position: Home > Articles > Biological Function and Anti-Inflammatory Mechanism of Vitamin B_6 Chinese Journal of Animal Nutrition 2023 (5) 2738-2747

维生素B_6的生物学功能及其抗炎作用机制

作  者:
欧阳经鑫;李秋粉;周华;黎观红
单  位:
江西农业大学动物科学技术学院
关键词:
维生素B_6;生物学功能;免疫调节;抗炎机制;应用
摘  要:
维生素B6是动物维持健康生长和正常生理功能所必需的微量营养素。它不仅作为辅酶参与机体的正常代谢反应如氨基酸、碳水化合物、脂类及核酸代谢,还具有神经调节、抗氧化、抗炎、免疫调节和抗肿瘤等多种生物学功能。血浆维生素B6的低水平状态与多种炎症性疾病的高患病风险存在密切的联系。这种反向关联被认为是维生素B6被动员到炎症部位用于调节色氨酸和鞘磷脂代谢,调节淋巴细胞的运输、数量和功能,抑制炎症信号通路,以发挥其免疫调节和抗炎特性。本文综述了维生素B6的生物学功能、潜在的抗炎机制及在饲粮中的应用,以期为其在畜牧生产中的应用提供参考。
译  名:
Biological Function and Anti-Inflammatory Mechanism of Vitamin B_6
作  者:
OUYANG Jingxin;LI Qiufen;ZHOU Hua;LI Guanhong;Jiangxi Province Key Laboratory of Animal Nutrition,College of Animal Science and Technology,Jiangxi Agricultural University;
关键词:
vitamin B_6;;biological function;;immunomodulation;;anti-inflammatory mechanism;;application
摘  要:
Vitamin B_6 is an essential micronutrient for the healthy growth and normal physiological function of animals.It not only participates in the normal metabolic reaction of the body as a coenzyme,but also has a variety of biological functions such as neuromodulation,antioxidant,anti-inflammatory,immunomodulatory and anti-tumor.Low plasma vitamin B_6 level status is strongly associated with higher risk of a variety of inflammatory disease.The inverse association is thought to be the result of mobilization of vitamin B_6 to the site of inflammation,for use of regulation of tryptophan and sphingolipid metabolism,modulation of lymphocyte trafficking,number and function,and inhibition of inflammatory signaling pathway,to exert their immunomodulatory and anti-inflammatory properties.This article reviewed the biological functions,potential anti-inflammatory mechanism and application in feed of vitamin B_6,in order to provide reference for the application of vitamin B_6 in animal husbandry.[Chinese Journal of Animal Nutrition,2023,35(5):2738-2747]

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