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Position: Home > Articles > The Clinical Comparison of Hepatonephric Effects of Sevoflurane,Halothane,Isoflurane in Dogs Chinese Journal of Animal and Veterinary Sciences 2002,33 (5) 473-476

七氟醚、氟烷、异氟醚对犬肝肾功能影响的临床比较

作  者:
熊惠军;Sabine Tacke;Ernst Schimke
单  位:
Justus-Liebig-UniversitaetGiessen 广州510642;华南农业大学动物医学系;D35392Giessen;Kleintierchirurgie;Justus-Liebig-UniversitaetGiessen;Germany
关键词:
七氟醚;氟烷;异氟醚;肝;肾;犬
摘  要:
为评价七氟醚对肝肾功能的影响 ,并与氟烷和异氟醚作比较 ,对动物医院就诊的心肺功能正常 ,拟作手术治疗的 6 1头患犬进行麻醉试验。所有犬均以l 美散痛和安定作为麻醉前给药。分别以 1 5 %七氟醚、1 0 %氟烷、1 5 %异氟醚维持手术麻醉。所有 3组中无一组可见肝肾毒性副作用。至七氟醚麻醉后 48h ,GLDH ,AST ,ALT ,γ GT ,总胆红素 ,AP ,尿素氮和肌酐显示正常。
译  名:
The Clinical Comparison of Hepatonephric Effects of Sevoflurane,Halothane,Isoflurane in Dogs
作  者:
XIONG Hui-jun 1,TACKE Sabine 2,SCHIMKE Ernst 2 (1.Department of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China; 2.Kleintierchirurgie,Justus-Liebig-Universitaet Giessen,D-35392 Giessen,Germany)
关键词:
Sevoflurane;Halothane;Isoflurane;Liver;Kidney;Dog
摘  要:
To evaluate hepatonephric effects of sevoflurane,compared with halothane and isoflurane,the study was carried out on 61 cardiopulmonary healthy dogs,which were taken to the Veterinary Hospital for elective surgery.All dogs were intravenously premedicated with l -methadone and diazepam.The surgical plane of anaesthesia was maintained with 1.5% sevoflurane,1.0% halothane or 1.5% isoflurane respectively.Neither hepatotoxic nor nephrotoxic side effects were seen in one of the 3 groups.GLDH,AST,ALT,γ-GT,total bilirubin,AP,urea and creatinine showed normal values until 48 hours after sevoflurane anaesthesia.

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