Position: Home > Articles > Effects of Piperphentonamine Hydrochloride on QT Intervals of ECG in New Zealand Rabbits
Progress in Veterinary Medicine
2018
(5)
73-77
盐酸椒苯酮胺对新西兰兔心电图QT间期的影响
作 者：
江丽;欧思琳;吴云;赵月;陈灶妹;陈柯君;吴庆荣;朱晋辉;李茹冰
关键词：
盐酸椒苯酮胺(PPTA);新西兰兔;QT间期延长;心电图研究;心律失常
摘 要：
旨在观察不同剂量盐酸椒苯酮胺(piperphentonamine hydrochloride,PPTA)对新西兰兔心电图QT间期(从QRS波开始到T波结束时的时限)的影响。将40只新西兰兔随机分为5组,每组8只,分别为溶剂对照组(5%葡萄糖)、PPTA低(2.5mg/kg)、中(10mg/kg)、高(25mg/kg)剂量组以及阳性对照组(9mg/kg索他洛尔),采用体表心电图技术,通过Pclab-530C生物医学信号采集处理系统记录各组新西兰兔注射相应药物后PPTA标准肢体Ⅱ导联心电图变化。结果表明,2.5mg/kg、10mg/kg PPTA在缓慢给药后不引发QT间期延长,25mg/kg PPTA在缓慢给药后15min内引起QT间期轻度延长(P<0.05);PPTA对QT间期的影响主要发生在给药后0~15min,45min后基本恢复正常。因此,低、中剂量盐酸椒苯酮胺(PPTA)不引发新西兰兔心电图QT间期延长,安全性较高,高剂量可能有引发QT间期延长风险,提示在临床用药时需要注意药物使用剂量,以防QT间期延长和心律失常的发生。
译 名：
Effects of Piperphentonamine Hydrochloride on QT Intervals of ECG in New Zealand Rabbits
作 者：
JIANG Li;OU Si-lin;WU Yun;ZHAO Yue;CHEN Zao-mei;CHEN Ke-jun;WU Qing-rong;ZHU Jin-hui;LI Ru-bing;Southern Medical University;Guangzhou General Hospital of Guangzhou Military Command;
单 位：
JIANG Li%OU Si-lin%WU Yun%ZHAO Yue%CHEN Zao-mei%CHEN Ke-jun%WU Qing-rong%ZHU Jin-hui%LI Ru-bing%Southern Medical University%Guangzhou General Hospital of Guangzhou Military Command
关键词：
piperphentonamine hydrochloride(PPTA);;New Zealand rabbit;;ECG;;QT interval prolongation;;arrhythmia
摘 要：
This study aimed to observe the effects of different doses of piperphentonamine hydrochloride(PPTA)on QT intervals in New Zealand rabbits.Forty New Zealand rabbits were randomly divided into 5 groups(n=8):solvent control group(5% glucose),low-(2.5 mg/kg),medium-(10 mg/kg),high-dosage PPTA groups(25 mg/kg)and positive control group(9 mg/kg sotalol).The surface ECG technique was used to record the ECG change of rabbits in the lead II dent way after giving corresponding drugs by Pclab-530 Cbiomedical signal acquisition and processing system.Result showed that 2.5 mg/kg and 10 mg/kg PPTA did not cause QT interval prolongation after administration,25 mg/kg PPTA led to QT interval prolongation slightly within 15 min after injection(P<0.05);The influence of PPTA on QT interval mainly happened after drug injection from 0 min to 15 min,45 min later,QT interval returned to normal.Therefore,low-dosage and medium-dosage of PPTA do not cause QT interval prolongation in New Zealand rabbits,with high security,high-dosage of PPTA has a potential risk of arrhythmia,and suggest that when we use the drug in clinic,we should pay more attention to the dose of it to prevent the QT prolongation and arrhythmia.
导出引用
计量
文章访问数: 5
HTML全文浏览量: 0
PDF下载量: 0
所属期刊
