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当前位置: 首页 > 文章 > miR-502在犬乳腺癌中的表达及意义 畜牧兽医学报 2020 (1) 193-197
Position: Home > Articles > Expressions of miR-502 in Canine Breast Cancer and Clinical Significance Chinese Journal of Animal and Veterinary Sciences 2020 (1) 193-197

miR-502在犬乳腺癌中的表达及意义

作  者：
任晓丽;范玉营;石冬梅;田传文;卢水龙;刘云
单  位：
河南牧业经济学院动物医药学院;东北农业大学动物医学学院
关键词：
乳腺癌;犬;miR-502;基因表达
摘  要：
旨在研究微小miR-502(cfa-miRNA-502)在犬乳腺癌组织中的表达情况及其临床意义。采用实时定量PCR方法检测30例犬乳腺癌组织及癌旁正常组织中miR-502的表达水平,分析miR-502表达与犬乳腺癌组织临床病理特征(年龄、肿瘤大小、组织学分级和转移)的关系。结果显示:与癌旁组织相比,犬乳腺癌组织中miR-502的表达水平显著升高,差异具有统计学意义(P<0.01);miR-502表达与犬乳腺癌的组织学分级与转移有关(P<0.05),但与年龄和肿瘤大小无关(P>0.05)。本研究提示miR-502在犬乳腺癌组织中表达上调,其表达与犬乳腺肿瘤的发生、发展有一定关系,miR-502可能作为犬乳腺癌诊断的肿瘤标记物。
译  名：
Expressions of miR-502 in Canine Breast Cancer and Clinical Significance
作  者：
REN Xiaoli;FAN Yuying;SHI Dongmei;TIAN Chuanwen;LU Shuilong;LIU Yun;College of Veterinary Medicine, Henan University of Animal Husbandry of Economy;College of Veterinary Medicine, Northeast Agricultural University;
关键词：
breast cancer;;canine;;miR-502;;gene expression
摘  要：
The aim of this study was to investigate the expression level of miR-502 and its clinical significance in canine breast cancer tissues. A total of 30 cases of canine breast cancer tissues and normal adjacent tissues were enrolled in this study. The expression levels of miR-502 were detected by real-time quantitative polymerase chain reaction(qRT-PCR). The relationship between the levels of miR-502 and the clinicopathological features(age, tumor size, histological grade and metastasis state) of canine breast cancer were analyzed. The experiment results showed that compared with the adjacent normal tissues, the levels of miR-502 transcription in canine breast cancer tissues increased significantly(P<0.01). The transcription of miR-502 was related with histological grade and metastasis in canine breast cancer(P<0.05); but not related with tumor size or age(P>0.05). The miR-502 transcription level is up-regulated in canine breast cancer that related with tumorigenesis and progression of canine breast cancer. miR-502 can be used as a tumor marker for diagnosis prediction of canine breast cancer.

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