关键词：
三氯乙酰氯;三氯吡啶酚;溶剂;催化剂;压力
摘 要：
[目的]进一步优化三氯乙酰氯合成三氯吡啶酚的工艺。[方法]以三氯乙酰氯、丙烯腈为原料,在催化剂作用下,通过加成环化、芳构化2步法合成3,5,6-三氯吡啶-2-酚,考察溶剂类型、催化剂用量、助催化剂类型和反应压力对三氯吡啶酚收率的影响。[结果]三氯乙酰氯路线合成三氯吡啶酚的优化工艺为:三氯乙酰氯、丙烯腈为原料,1.3 g/46 g(三氯乙酰氯)氯化亚铜为催化剂,二氯苯为溶剂,此条件下三氯吡啶酚的收率可达55%。微负压条件有利于及时排除反应过程中产生的氯化氢,降低安全隐患,而添加助催化剂对反应效果无显著促进作用。[结论]该研究确定了三氯乙酰氯路线合成三氯吡啶酚的最佳工艺。
译 名：
Optimization on Synthesis Technology of 3,5,6-Trichloropyridine-2-phenol
作 者：
SHEN Fa-zhi et al(Department of Chemical Engineering,Yangzhou University of Polytechnic,Yangzhou,Jiangsu 225127)
关键词：
Trichloro-acetic chloride;Trichloropyridine phenol;Solvent;Catalyst;Pressure
摘 要：
[Objective] The purpose was to further optimizing the synthesis technology of trichloropyridine phenol from trichloro-acetic chloride.[Method] With trichloro-acetic chloride and acrylonitrile as raw materials,under the action of catalyst,3,5,6-trichloropyridine-2-phenol was synthesized through 2 steps of adding cyclization and aromatization and the influences of solvent types,catalyst dosage,promoter types and response pressure on the yield rate of trichloropyridine phenol were investigated.[Result] The optimized synthesis technology of trichloropyridine phenol from trichloro-acetic chloride was that under the condition with trichloro-acetic chloride and acrylonitrile as raw materials,1.3 g/46 g(trichloro-acetic chloride) cuprous chloride as catalyst and dichloro-benzene as solvent,the yield rate of trichloropyridine phenol could reach 55%.Micro negative pressure was favorable to deplete chloride hydrogen produced from reaction timely so as to decrease hidden danger.And the addition of promoter had no promoting action on reaction effect.[Conclusion] The optimum synthesis technology of trichloropyridine phenol from trichloro-acetic chloride was confirmed in this research.
