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当前位置: 首页 > 文章 > 传染性腔上囊病病毒广西流行株免疫原性的研究 中国兽医科学 2009 (10) 880-885
Position: Home > Articles > Immunogenicity of prevalent infectious bursal disease virus strains in Guangxi,China Chinese Veterinary Science 2009 (10) 880-885

传染性腔上囊病病毒广西流行株免疫原性的研究

作  者：
黄志永;韦平;吴俊姬;陆有飞;李葆泓
单  位：
广西大学养禽与禽病研究所广西民族大学化学与生态工程学院;广西融安县水产畜牧兽医局;广西生物制品厂;广西大学养禽与禽病研究所
关键词：
传染性腔上囊病病毒;免疫原性;油乳剂疫苗;最佳免疫剂量;免疫效力
摘  要：
分别制备传染性腔上囊病病毒(IBDV)广西流行毒株040124、BH11、TSC-2(9)和YL052以及参考强毒株CJ801-BKF的灭活油乳剂疫苗(OEV)及其多价OEV,分别进行IBD商品疫苗毒株B87(in)和FW2512对4个广西流行毒株的攻毒免疫保护试验、流行毒株间的免疫交叉保护试验、多价OEV不同免疫剂量及其与CJ801-BKF株OEV的免疫保护对比试验。结果显示,2个IBD商品疫苗均不能对4个流行毒株提供完全的保护;4个流行毒株的OEV对同源毒株的攻毒均可产生100%保护,其中040124株OEV的交叉免疫保护性最好;在毒株免疫组与未免疫组免疫器官指数的比较中发现,TSC-2(9)株OEV免疫鸡的免疫器官受病毒的损伤程度最严重,而040124、BH11和YL052株OEV的免疫均能较好地保护鸡的免疫器官免受病毒的损伤;多价OEV 3个免疫剂量的免疫保护指数(IPI)为80%~100%,1 mL免疫组的IPI显著高于0.25 mL免疫组(P<0.05),而1 mL免疫组与0.5 mL免疫组差异不显著(P>0.05);多价OEV的免疫效力显著高于毒株YL052、TSC-2(9)和CJ801-BKF的OEV(P<0.05)。结果表明,本研究制备的多价灭活疫苗适用于本地IBD的防制。
译  名：
Immunogenicity of prevalent infectious bursal disease virus strains in Guangxi,China
作  者：
HUANG Zhi-yong1,2,WEI Ping1,WU Jun-ji1,LU You-fei1,LI Bao-hong1,ZHONG Ya-ting1,YANG Xiu-ying1,HE Xiu-miao3(1.Institute for Poultry Science and Health,Guangxi University,Nanning 530005,China;2.Guangxi Rong'an Bureau of Fishery,Animal Husbandry and Veterinary Medicine,Rong'an 545400,China;3.Guangxi University for Nationalities,Nanning 530006,China)
关键词：
infectious bursal disease virus;immunogenicity;oil-emulsion vaccine;optimal immunization dosage;immune efficiency
摘  要：
The immune protection tests of the infectious bursal disease(IBD) commercial vaccine strains B87(in) and FW2512 against the four Guangxi isolates 040124,BH11,TSC-2(9) and YL052,the cross-protective immunity tests among the four isolates,the protection contrast tests of the multivalent inactivated oil-emulsion vaccine(OEV) from isolates 040124,BH11 and TSC-2(9) at different immune dosages and a protection contrast test of the multivalent inactivated OEV with the OEV developed from the reference virulent strain CJ801-BKF were conducted respectively.The results showed that the two commercial vaccines could not provide full protection against the four field isolates,while 100% protections were obtained with the OEVs of the four isolates against the homogeneous viruses,and the OEV of 040124 provided the highest cross-protection.Birds vaccinated with OEVs of isolate TSC-2(9) had the lowest protection of immune organs against the challenge of isolates by having significant difference in immune organs index(IOI) compared with the un-infected control birds(P<0.05),while the birds vaccinated with OEVs of isolates 040124,BH11 and YL052 had no significant difference in IOI compared with the uninfected control birds(P>0.05).Immune protection index(IPI) of the multivalent OEV with 3 different immune dosages of 1mL,0.5mL and 0.25mL was from 80% to 100%,per bird dosages 1mL had significant higher IPI than that of dosage 0.25mL(P<0.05),while dosages 1mL and 0.5mL had no significant difference on IPI(P>0.05).These results demonstrated that the immune efficacy of multivalent OEV was the best among all the OEVs tested,which might be used for the prevention and control of IBD in Guangxi.

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