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Position: Home > Articles > Research Progress of the Genes KIT and MLPH for Melanin Pigmentation in Animals Newsletter of Sericultural Science 2015,35 (3) 16-21

动物黑色素沉着基因KIT和MLPH的研究进展

作  者:
刘杰;刘毅;胡彦竞科;何大乾;刘安芳
单  位:
上海市农业科学院;西南大学荣昌校区
关键词:
KIT基因;MLPH基因;黑色素;黑素小体
摘  要:
动物不同的肤色和被毛颜色与黑色素沉着的种类和数量有关,而黑色素的沉着需要众多基因的参与,涉及KIT和MLPH基因等,前者在黑色素的生成过程中发挥重要的作用,后者在黑素小体转运的过程中具有关键的作用。先前的研究表明,KIT基因的突变,导致动物被毛颜色的改变,同时,KIT基因突变还与人类疾病有关;MLPH基因的变异影响动物被毛的颜色,导致动物被毛颜色变淡。本文主要对黑素细胞的形成、黑色素的合成、黑色素的转运和KIT及MLPH基因的研究进行概述,旨在为黑色素沉着机制、动物皮肤和被毛的着色研究提供参考。
译  名:
Research Progress of the Genes KIT and MLPH for Melanin Pigmentation in Animals
作  者:
LIU Jie;LIU Yi;HU-YAN Jing-ke;HE Da-qian;LIU An-fang;Southwest University (Rongchang Campus);Shanghai Academy of Agricultural Sciences;
关键词:
KIT gene;;MLPH gene;;melanin;;melanosome
摘  要:
The various skin colors and coat colors in animals are related to the type and amount of melanins deposited within the melanosomes.There are many genes participating in melanin deposition,involving KIT,MLPH and others.KIT and MLPH genes play important roles in melanogenesis and melanosome transfer,respectively.Previous studies have shown that mutations of KIT lead to phenotype changes in coat color of animals,while mutations of KIT are associated with human diseases.Variations of MLPH influence the coat colors in animals,resulting in dilution of coat color pigmentation.This paper presents an overview of melanocyte growth and development,melanin biosynthesis and transfer,and the research progress in KIT and MLPH genes in order that it may serve as important references for the study of the mechanisms of melanin deposition and skin,hair and plumage coloration.

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