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当前位置: 首页 > 文章 > 苦楝皮妊娠毒性作用及对妊娠早期小鼠子宫NK、IFN-γ和TNF-α含量的影响 畜牧兽医学报 2005,36 (7) 747-750
Position: Home > Articles > Pregnancy Toxicity and Effects of Water Extract of Cortex Toosendan on the Uterine Immunity during Early Pregnancy in Mice Chinese Journal of Animal and Veterinary Sciences 2005,36 (7) 747-750

苦楝皮妊娠毒性作用及对妊娠早期小鼠子宫NK、IFN-γ和TNF-α含量的影响

作  者：
翟向和;宫新城;李清艳;李新民;刘占民;钟秀会
单  位：
河北农业大学动物科技学院;河北农业大学中兽医学院
关键词：
苦楝皮;小鼠;NK细胞;IFNγ;IFNα;流产
摘  要：
Water extract of Cortex toosendan (1∶1) was given by oral admistration to the pregnant mice on day 7 in order to study its toxicity. Embryo livability was examined. The natural killer cells in the uterine decidua were detected by immunohistochemistry. The Th1 cytokines IFN-γ and TNF-α in the uterine lysates were analyzed by ELISA. The results showed that Cortex toosendan is toxic to embryo, and that the toxicity is related to the enhancement of Th1 responses at the maternal-fetal interface, with the increase of NK cell counts, IFN-γ and TNF-α concentrations in pregnant uterus.
译  名：
Pregnancy Toxicity and Effects of Water Extract of Cortex Toosendan on the Uterine Immunity during Early Pregnancy in Mice
作  者：
ZHAI Xiang-he~1, GONG Xin-cheng~1, LI Qing-yan~1, LI Xin-min~1, LIU Zhan-min~1, ZHONG Xiu-hui~2 (1. College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Dingzhou 073000, China; 2. College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001, China )
关键词：
Cortex toosendan; mouse; NK cells; IFN-γ; TNF-α; abortion
摘  要：
Water extract of Cortex toosendan (1∶1) was given by oral admistration to the pregnant mice on day 7 in order to study its toxicity. Embryo livability was examined. The natural killer cells in the uterine decidua were detected by immunohistochemistry. The Th1 cytokines IFN-γ and TNF-α in the uterine lysates were analyzed by ELISA. The results showed that Cortex toosendan is toxic to embryo, and that the toxicity is related to the enhancement of Th1 responses at the maternal-fetal interface, with the increase of NK cell counts, IFN-γ and TNF-α concentrations in pregnant uterus.

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