当前位置: 首页 > 文章 > 古尼虫草Cordyceps gunnii(Berk.)Berk.无性型的镇痛物质研究(英文) 华中农业大学学报 2004 (1) 40-43
Position: Home > Articles > Analgesic Substance from The Anamorph of Cordyceps gunnii(Berk. )Berk. Journal of Huazhong Agricultural University 2004 (1) 40-43

古尼虫草Cordyceps gunnii(Berk.)Berk.无性型的镇痛物质研究(英文)

作  者:
梁宗琦;常胜军;刘爱英
单  位:
贵州大学真菌资源研究所
关键词:
古尼虫草;古尼拟青霉;镇痛物质
摘  要:
报道了分离提纯自古尼虫草(Cordyceps gunii)一个单子囊孢子的无性古尼拟青霉(Paecilo—myces gunii)5—19菌株,菌丝培养物镇痛组分的基本理化性质和菌丝不同培养条件对其药理作用的影响。结果表明:虫草菌丝的镇痛组分是水溶性的;镇痛组分最佳提取溶剂为水,最佳提取方法为热提取法;古尼虫草镇痛组分对冰醋酸所致小鼠扭体抑制率在剂量0.05 g/g(生药/小鼠)范围与剂量成正相关;在所试pH值范围内(pH1~10),其镇痛效果无明显变化。当pH>11时,镇痛作用强度下降。镇痛组分有较好的热稳定性。在100℃加热1 h,它对冰醋酸所致的小鼠扭体抑制率仍为100%;培养基组成和培养温度在所试条件下,不仅影响菌丝的生物量,而且影响菌丝浸出物的镇痛效果。
译  名:
Analgesic Substance from The Anamorph of Cordyceps gunnii(Berk. )Berk.
作  者:
Liang Zongqi Chang Shengjun Liu Aiying (Institute of Fungus Resources, Guizhou University ,Guiyang 550025)
关键词:
Corayceps gunnii; Paecilomyces gunnii; analgesic substance
摘  要:
A sort of analgesic substance is extracted from the mycelia of Paecilomyces gunnii Liang, an ana-morph of Cordyceps. Some physical and chemical characters of this substance are elucidated. The analgesic substance from the mycelia of Paecilomyces gunnii Liang & Liu is water soluble. The best extractive method from the mycelia is soaking-heating extraction. The analgesic substance can be solved in 90% alcohol ,but can't be solved in ether or methanol. The molecular weight of the analgestic substance from Paecilomyces gunnii Liang & Liu is 12 000~14 000 Da. Infrared spectrum of the analgesic substance shows that it doesn't contain the structure of Do-lantin's group. The analgesic substance is stable in pH

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