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Position: Home > Articles > Study on Analgesic Effect of Mycelia Extract from Paecilomyces gunnii Guizhou Agricultural Sciences 2009,37 (3) 60-62

古尼拟青霉菌丝体提取物镇痛作用研究

作  者:
陈小荣;朱国胜;刘作易;杨小生;梁冰;许琼明;刘艳丽;林海鸣
单  位:
贵州省·中科院天然产物化学重点实验室;贵州大学;贵州省农业生物技术重点实验室;贵阳医学院;苏州大学
关键词:
古尼虫草;古尼拟青霉;镇痛作用
摘  要:
采用小鼠醋酸扭体法和热板法2种疼痛模型试验,以灌胃和皮下注射2种给药方式,观察古尼虫草提取物对小鼠疼痛反应和小鼠扭体次数的影响,探讨了古尼虫草(Cordyceps gunnii(Berk.)Berk)无性型——古尼拟青霉(Paecilomyces gunnii Liang)菌丝体提取物的镇痛作用。结果表明,无论是灌胃给药还是皮下注射给药,醋酸扭体法,古尼拟青霉菌丝体水提物和醇提物都能明显抑制小鼠疼痛引起的扭体,热板法试验效果则不明显。古尼虫草具有明显的外周镇痛作用,中枢镇痛作用不明显。
译  名:
Study on Analgesic Effect of Mycelia Extract from Paecilomyces gunnii
作  者:
CHEN Xiao-rong1,2,ZHU Guo-sheng2,LIU Zuo-yi2*,YANG Xiao-sheng3, LIANG Bing4,XU Qiong-ming5,LIU Yan-li5,LIN Hai-ming5(1.College of Life Science,Guizhou University,Guiyang,Guizhou 550025;2.Guizhou Key Laboratory of Agricultural Biotechnology,Guiyang,Guizhou 550006;3.Chinese Academy of Sciences Natural Products Drug Chemical Key Laboratory,Guiyang,Guizhou 550006;4.Guiyang Medical College,Guiyang,Guizhou 550004;5.College of Pharmacy,Suzhou University,Suzhou,Jiangsu,215123,China)
关键词:
Cordyceps gunnii;Paecilomyces gunnii;analgesic effect
摘  要:
The analgesic effects of mycelia extract from Paecilomyces gunnii Liang,anamorph of Cordyceps gunnii,were studied by using pain models of acetic acid induced writhing and hot-plate test in mice with intragastric administration and hypodermic injection.By observation of and writhing times in mice,the results show that either intragastric administration or hypodermic injection with the water or alcohol extracts from mycelia P.gunnii Liang can reduce the writhing times in mice remarkably,but the effect in the hot-pate model is not very obvious.It is said that Cordyceps gunnii(Berk.) Berk has peripheral analgesic effect and not obvious central analgesic effect.

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