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当前位置: 首页 > 文章 > 磺胺噻唑在山羊体内的药物动力学研究 西北农林科技大学学报(自然科学版) 2014,42 (11) 8-12
Position: Home > Articles > Pharmacokinetics of sulfathiazole in goats Journal of Northwest A & F University(Natural Science Edition) 2014,42 (11) 8-12

磺胺噻唑在山羊体内的药物动力学研究

作  者：
翟新贵;张有亮;赵彪;马丙婷;孙睿
单  位：
西北农林科技大学动物医学院;西北农林科技大学动物医学院鹤壁职业技术学院
关键词：
磺胺噻唑;山羊;药物动力学
摘  要：
【目的】研究磺胺噻唑在山羊体内的药物动力学过程,为该药在兽医临床的合理应用提供依据。【方法】用磺胺噻唑对照品配制标准溶液,建立磺胺噻唑的紫外测定方法。给6只山羊分别静脉注射剂量为70mg/kg的磺胺噻唑钠,于注射前和注射后5,10,15,30,45,60,120,180,240和300min分别颈静脉采血,测定血药质量浓度,用残数法拟合药-时曲线,计算其药物动力学参数。【结果】磺胺噻唑在山羊体内的药物动力学符合二室模型。药物动力参数消除相初始质量浓度B为(198.37±64.63)mg/L,分布相半衰期t1/2α为(0.05±0.04)h,消除相半衰期t1/2β为(0.89±0.21)h,表观分布容积Vd为(0.15±0.07)L/kg,体内消除率CL(s)为(0.28±0.08)mg/(kg·h),有效血药浓度维持时间为(1.58±0.58)h。【结论】磺胺噻唑在山羊体内为短效药物。
译  名：
Pharmacokinetics of sulfathiazole in goats
作  者：
ZHAI Xin-gui;ZHANG You-liang;ZHAO Biao;MA Bing-ting;SUN Rui;LI Yin-qian;College of Veterinary Medicine,Northwest A&F University;Hebi College of Vocation and Technology;
关键词：
sulfathiazole(ST);;goats;;pharmacokinetics
摘  要：
【Objective】Pharmacokinetics of sulfathiazole(ST)in goats was studied to provide the basis for its rational application in veterinary clinical.【Method】ST reference substance was used to prepare standard solution and a UV measurement method was established.ST was given to 6goats intravenously at a dose of 70mg/kg of ST-Na.Blood samples were taken from jugular vein before injection and 5,10,15,30,45,60,120,180,240 and 300min after injection.Then concentrations of ST in serum were determined and concentration-time relationship was fitted by residual method to calculate the pharmacokinetic parameters of ST in goats.【Result】The two-compartment open model was suitable to describe the pharmacokinetics of ST in goats.Pharmacokinetic parameters were:initial concentration(198.37±64.63)mg/L,t1/2α(0.05±0.04)h,t1/2β(0.89±0.21)h,Vd(0.15±0.07)L/kg,CL(s)(0.28±0.08)mg/(kg·h),and tcp(1.58±0.58)h.【Conclusion】ST was proved to be a short-acting medication to goats.

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