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Position: Home > Articles > Studon Pharmacokinetics of Sulfathiazole Sodium in Rabbits Progress in Veterinary Medicine 2014,35 (4) 85-88

磺胺噻唑在家兔体内的药物动力学研究

作  者:
蒿彩菊;赵飚;张有亮;李引乾
单  位:
西北农林科技大学动物医学院
关键词:
磺胺噻唑;家兔;药物动力学
摘  要:
为了给兽医临床合理用药提供依据,分析了磺胺噻唑在家兔体内的药物动力学过程。给6只家兔分别静脉注射剂量为140mg/kg的磺胺噻唑,12h内不同时间经耳缘静脉采血9次,用紫光可见光光度计测定血药质量浓度。结果表明,磺胺噻唑在兔体内的药物动力学配置均符合一室模型,其药-时最佳方程为ρ=189.95e-0.26t。药物动力参数,初始浓度C为189.95mg/L;末端消除速率Ke为0.988 1/h,表观分布容积V(C)为0.800L/kg;末端消除半衰期t1/2(Ke)为0.788h;药-时曲线下面积AUC为212.100mg/(L·h)-1;体内清除率CL(s)为0.770L/(kg·h)-1;有效血药浓度维持时间为1.58h。提示磺胺噻唑在兔体内为短效药物。
译  名:
Studon Pharmacokinetics of Sulfathiazole Sodium in Rabbits
作  者:
HAO Cai-ju;ZHAO Biao;ZHANG You-liang;LI Yin-qian;College of Veterinary Medicine,Northwest A&F University;
关键词:
sulfathiazole sodium;;rabbit;;pharmacokinetics
摘  要:
To study the pharmacokinetics of sulfathiazole sodium(ST)in rabbits and lay a foundation for clinic use,6rabbits were intravenously injected with ST at 140mg/kg dosage.The blood simples were collected 9times during 12h.Pharmacokinetic parameters of ST in rabbits were calculated and analyzed.The results showed that the one-compartment open model with first-order disabsorption factor adequately describes whole blood ST disposition and the best ST concentration-time equation is:C=189.89e-0.26t.Pharmacokinetic parameters are as follows:C:189.95mg/L,Terminal elimination rate:0.988 1/h,Vc:0.800L/kg,Terminal elimination half-life:t1/2(Ke):0.788h,AUC:212.100mg/(L·h)-1,CL(s):0.770L/(kg·h)-1,tcp:1.58h.It can be seen that pharmacokinetic disabsorption of ST in rabbits is a rapidelimination process.

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