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氟吡菌胺的合成工艺研究

作  者:
高玉清;石强强;潘炳庆;耿来红;徐世栋;张生芳
单  位:
甘肃省化工研究院
关键词:
新型杀菌剂;氟吡菌胺;2,3-二氯-5-三氟甲基吡啶;合成
摘  要:
以2,3-二氯-5-三氟甲基吡啶等为起始原料,与硝基甲烷经亲核取代生成3-氯-2-硝基甲基-5-三氟甲基吡啶,再通过氯化亚锡还原得到2-氨基甲基-3-氯-5-三氟甲基吡啶,最后与2,6-二氯苯甲酰氯缩合得到氟吡菌胺。对其合成工艺(反应温度、时间、原料物质的量之比等)进行了讨论,产品及中间体结构经~1H NMR表征确认。在优化条件下,反应总收率为59.5%。该工艺操作简单,条件温和,收率较高。
译  名:
Synthesis of Fluopicolide
作  者:
GAO Yu-qing;SHI Qiang-qiang;PAN Bing-qing;GENG Lai-hong;XU Shi-dong;ZHANG Sheng-fang;Gansu Research Institute of Chemical Industry;
关键词:
novel fungicide;;fluopicolide;;2,3-dichloro-5-(trifluoromethyl)pyridine;;synthesis
摘  要:
The target product fluopicolide was synthesized from 2,3-dichloro-5-(trifluoromethyl)pyridine via nucleophilic substitution reaction,reduction reaction,condensation reaction.The influences of the synthetic technological route were investigated,and the structures of key intermediates and fluopicolide were confirmed by1 H NMR.Under optimized conditions,the total yield was 59.5%.This process was simple,the condition was mild.

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