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Position: Home > Articles > Structure and Function of Acetyl-CoA Carboxylase Journal of Anhui Agricultural Sciences 2006,34 (3) 413-414+416

乙酰辅酶A羧化酶(ACC)的结构与功能

作  者:
韩春春;王继文;魏守海
单  位:
四川农业大学动物科技学院
关键词:
乙酰辅酶A羧化酶;结构;功能
摘  要:
乙酰辅酶A羧化酶(ACC)催化乙酰辅酶A形成丙二酸单酰辅酶A的羧化作用,是在脂肪酸合成和代谢中起重要作用的中间代谢物。ACC包括ACCα和ACCβ两种形式,被不同的基因编码。ACC(α265 kDa)主要在脂肪生成活跃的肝脏、脂肪组织和乳腺中表达。ACC(β275 kDa)主要在β-氧化作为主要能量来源的骨骼肌和心脏中表达。对ACC的结构特点和基本功能进行了探讨。
译  名:
Structure and Function of Acetyl-CoA Carboxylase
作  者:
HAN Chun-chun et al (Animal Science and Technology,College of Sichuan Agricultural University,Yaan,Sichuan 625014)
关键词:
ACC;Structure;Function
摘  要:
Acetyl-CoA carboxylase(ACC) catalyzes the carboxylation of acetyl-CoA to produce malonyl-CoA.ACC is an important enzyme of regulating fatty acid synthesis metabolism.There are two ACC isoforms that are encoded by distinct genes.ACC α(260 kDa) is the principal isoform expressed in tissues that exhibit high rates of fatty acid synthesis such as liver,adipose tissue,and mammary gland.ACC β(280 kDa) is the major isoform observed in heart and skeletal muscle,where it is thought to function primarily in the regulation of β-oxidation of fatty acids.In this article the structure characteristics and basic functions of ACC were mainly discussed.

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