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当前位置: 首页 > 文章 > 牛磺鹅去氧胆酸对小鼠脾脏中白介素-2基因表达的影响 中国畜牧兽医 2009,36 (3) 67-72
Position: Home > Articles > Study on Effect of Taurochenodeoxycholic Acid on Gene Expression of Interleukin-2 in the Spleen of Mouse China Animal Husbandry & Veterinary Medicine 2009,36 (3) 67-72

牛磺鹅去氧胆酸对小鼠脾脏中白介素-2基因表达的影响

作  者：
李培锋;刘明强;关红
单  位：
内蒙古农业大学动物科学与医学学院
关键词：
牛磺鹅去氧胆酸;实时定量RT-PCR;IL-2
摘  要：
探讨牛磺鹅去氧胆酸(taurochenodeoxycholic acid,TCDCA)的抗炎和免疫调节作用机理。采用实时定量RT-PCR技术检测正常小鼠和免疫抑制模型小鼠脾脏内白介素-2(IL-2)基因mRNA水平表达量的变化。高剂量TCDCA组(0.2g/kg体重)和低剂量TCDCA组(0.1g/kg体重)小鼠脾脏组织内IL-2基因mRNA水平的表达量极显著地高于蒸馏水组(P<0.01);免疫抑制模型高剂量TCDCA和低剂量TCDCA组的小鼠脾脏组织内IL-2基因mRNA水平的表达量均极显著(P<0.01)高于免疫抑制模型,且免疫抑制模型低剂量TCDCA组显著(P<0.05)高于蒸馏水组。TCDCA的抗炎和免疫调节作用与其提高IL-2基因mRNA水平的表达量有关。
译  名：
Study on Effect of Taurochenodeoxycholic Acid on Gene Expression of Interleukin-2 in the Spleen of Mouse
作  者：
LI Pei-feng,LIU Ming-qiang,GUAN Hong(College of Animal Science and Medicine,Inner Mongolia Agricultural University,Hohhot 010018,China)
关键词：
taurochenodeoxycholic acid;real time RT-PCR;interleukin-2
摘  要：
To investigate the mechanism of action of anti-inflammatory and immunological regulation,the change of interleukin-2 gene in the level of mRNA in the spleen of healthy and immunosuppressive mouse was detected with the technology of real time RT-PCR.Compared to the control group,the gene expression of interleukin-2 in the spleen of mouse both high dose(0.20 g/kg body weight)and low does TCDCA(0.10 g/kg body weight)group could raised(P<0.01).Immunosuppressive model groups,high and low TCDCA could markedly revive the gene expression of interleukin-2 inhibited by ciclosporin A and the low TCDCA group markedly toped the control group.The mechanism of anti-inflammatory and immunoregulation has an intimate relationship with enhancing the gene expression of interleukin-2 inhibited in the level of mRNA in the spleen of mouse.

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