中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 玉米油与猪油调和油对小鼠肝脏PPARα、PPARγ、RXRα基因表达的影响 中兽医医药杂志 2016 (6) 5-9
Position: Home > Articles > Effects of corn oil and lard of blend oil on the expression of liver PPARα, PPARγ and RXRα in mice Journal of Traditional Chinese Veterinary Medicine 2016 (6) 5-9

玉米油与猪油调和油对小鼠肝脏PPARα、PPARγ、RXRα基因表达的影响

作  者：
严思思;王吉;周慧娟;谢文;黄海滨
单  位：
湖南农业大学动物医学院湖南畜禽安全生产协同创新中心湖南省长沙市岳麓区农业林业畜牧局;湖南农业大学动物医学院湖南畜禽安全生产协同创新中心;湖南农业大学动物医学院湖南烟村生态农牧科技股份有限公司
关键词：
玉米油;猪油;调和油;PPARs;RXRα;脂肪肝
摘  要：
目的:探讨不同剂量玉米油与猪油的1∶1调和油对小鼠PPARα、PPARγ、RXRα基因表达的影响。方法:将24只KM鼠随机分为3组,分别饲喂不同油脂含量的饲料,即3.8%推荐摄入量组(B组)、6.5%实际摄入量组(C)及对照组(A)。持续饲养8周并于每周一上午9:00称量每只小鼠体质量,8周后,采集肝脏组织,测定肝脏中的PPARα、PPARγ、RXRαm RNA表达水平。结果:小鼠体增长率与调和油剂量呈正相关;推荐摄入量组和实际摄入量组PPARαm RNA表达量均极显著低于对照组;推荐摄入量组PPARγm RNA表达量极显著高于对照组,实际摄入量组PPARγm RNA表达量极显著低于推荐摄入量组,实验组RXRαm RNA表达量与对照组比较无显著性差异。结论:每天摄入25 g玉米油和猪油的1∶1调和油能促进PPARγm RNA的表达,有效抑制非酒精性脂肪肝的形成。
译  名：
Effects of corn oil and lard of blend oil on the expression of liver PPARα, PPARγ and RXRα in mice
作  者：
YAN Si-si;WANG Ji;ZHOU Hui-juan;XIE Wen;HUANG Hai-bin;LI Xiao-wen;XIAO Xiang;WEN Li-xin;College of Veterinary Medicine, Hunan Agricultural University;Hunan Synthetic Innovation Center for Livestock Production Safety;Bureau of Agriculture, Forestry and Animal Husbandry in Yuelu District of Changsha City;
关键词：
corn oil;;lard oil;;blending oil;;PPARs;;RXRα;;fatty liver
摘  要：
Objective: To investigate the effect of different dose of corn oil and lard(1 ∶1) of blend oil on the expression of liver PPARα, PPARγ and RXRα in mice. Methods: 24 KM mice were randomly assigned into 3 groups fed with 3 different diets, namely 3.8% recommend intake group(B), 6.5% actual intake group(C) and control group(A). Bodyweight was weighed at Monday 9 o'clock for 8 weeks. Liver were collected to detect the levels of PPARα, PPARγ and RXRα m RNA.Results: In the research, body growth rate and the dose of corn oil and lard were positively correlated; Compared with control group, the level of PPARα m RNA in group B and group C was significantly decreased, the level of PPARγ m RNA in group B was significantly upregulated; Compared with group B, the level of PPARγ m RNA in group C was significantly decreased; compared with control group, the level of RXRα m RNA of test groups had no significant difference. Conclusion:The expression of PPARγ was upregulated while 25 g blend oil(corn oil to lard at 1 ∶1) to be intake everyday, which contribute to inhibit NAFLD.

相似文章

导出引用
计量
文章访问数: 14
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46