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当前位置: 首页 > 文章 > 三聚氰胺对雌性Wistar大鼠的慢性毒性研究 畜牧与饲料科学 2012,33 (4) 42-46
Position: Home > Articles > Study on the Chronic Toxicity of Melamine in Female Wistar Rats Animal Husbandry and Feed Science 2012,33 (4) 42-46

三聚氰胺对雌性Wistar大鼠的慢性毒性研究

作  者：
Guo Ju
单  位：
Inner Mongolia Yili Industrial Group C
关键词：
ma;extent;kidney;000;liver;dos
摘  要：
三聚氰胺(melamine,MA)对小鼠的经口LD50为4550mg/(kg.bw),急性毒性属于低毒物质。为证实和客观评价其慢性毒性,以每千克饲料500、1000和2000mgMA/kg饲料的剂量对6周龄雌性Wistar大鼠进行了6个月慢性毒性试验。结果表明,各剂量组雌性Wistar大鼠肾、肝和膀胱均有不同程度地功能异常和器质性病变;血液ALT、AST、CRE和UA等生化指标均有不同程度地升高,肾、肝和膀胱黏膜均有不同程度地病理变化或损伤;每千克饲料2000mgMA/kg饲料的剂量能够抑制大鼠生长和采食,肾病理变化显著,出现结石;染毒组大鼠脾脏、骨髓等未见病变;MA对大鼠的最大无作用剂量应小于(35.7±15.4)mg/(kg.bw.d)。
译  名：
Study on the Chronic Toxicity of Melamine in Female Wistar Rats
作  者：
SUN Mei-qi1,BAO Hai-quan1,MENG Lan-huan2,LI Cui-zhi2,GUO Jun1(1.College of Food Science and Engineering,Inner Mongolia Agricultural University,Hohhot 010018,China;2.Inner Mongolia Yili Industrial Group Co.,Ltd.,Hohhot 010080,China)
关键词：
melamine;Wistar rat;chronic toxicity;maximal no-effect dose
摘  要：
Melamine(MA) is a low-acute toxicity chemical with LD50 of 4 550 mg/(kg·bw) in mice.To verify and evaluate its chronic toxicity,500,1 000 and 2 000 mg MA per kilogram feed were fed to 6-week-old female Wistar rats for six months.The results showed that functional disorders and organic changes of kidney,liver and ladder of female Wistar rats to different extent were observed in each test group.The blood biochemical indices(such as ALT,AST,CRE and UA) increased to different extent.The histological abnormalities or damages to different extent were found in kidney,liver and bladder.In 2 000 mg MA/kg dose group,the growth and feed intake were inhibited and histological change or damage of kidney was significant,even kidney calculi appeared.In poisoned group,no histological abnormality was found in spleen and bone marrow of rats.Maximal no-effect dose of MA on rats should be less than(35.7±15.4) mg/(kg·bw·d).

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