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当前位置: 首页 > 文章 > 玫瑰精油抗血栓形成作用 食品科学 2011,32 (11) 270-272
Position: Home > Articles > Anti-thrombosis Effect of Rose Essential Oil FOOD SCIENCE 2011,32 (11) 270-272

玫瑰精油抗血栓形成作用

作  者：
厍文波;甘露;安晓晶;马建慧;陈虹;郑秋生;王振华
单  位：
新疆特种植物药资源教育部重点实验室石河子大学药学院
关键词：
玫瑰精油;血小板聚集;血栓形成
摘  要：
目的:研究玫瑰精油对大鼠体外全血血小板聚集以及大鼠动-静脉旁路血栓形成的影响。方法:大鼠颈总动脉取血后,随机分为溶剂对照组,阿司匹林阳性对照组,玫瑰精油高(100μg/mL)、中(50μg/mL)、低(25μg/mL)剂量组,分别采用血小板聚集诱导剂二磷酸腺苷(ADP)、钙离子载体(A23187)和CaCl2激发血小板聚集,以电阻法分别检测玫瑰精油对体外全血血小板聚集的抑制作用。取Wistar大鼠50只,均于手术前3d进行分组灌胃给药,即溶剂对照组,阿司匹林阳性对照组(30mg/(kg.d)),玫瑰精油(溶于注射用大豆油)高(100mg/(kg.d))、中(50mg/(kg.d))、低(25mg/(kg.d))剂量组,然后采用大鼠动-静脉旁路血栓形成法观察玫瑰精油对血栓形成的抑制作用。结果:玫瑰精油能显著抑制ADP、A23187、CaCl2诱导的大鼠血小板聚集和动-静脉旁路血栓的形成。
译  名：
Anti-thrombosis Effect of Rose Essential Oil
作  者：
SHE Wen-bo,GAN Lu,AN Xiao-jing,MA Jian-hui,CHEN Hong,ZHENG Qiu-sheng,WANG Zhen-hua(Key Laboratory of Xinjiang Endemic Phytomedicine Resources,Ministry of Education,School of Pharmacy, Shihezi University,Shihezi 832002,China)
关键词：
rose essential oil;platelet aggregation;thrombosis
摘  要：
Objective: To investigate the effect of rose essential oil on whole blood platelet aggregation and arteriovenous shunt thrombosis in rats.Methods: The platelet aggregation in whole blood samples from rats was induced by adenosine diphosphate(ADP),calcium ionophore(A23187) and CaCl2,respectively.The inhibitory effect of rose essential oil at the doses of 25,50 mg/L and 100 mg/L on platelet aggregation was measured by electric resistance method in vitro.Fifty male Wistar rats were randomly divided into 5 groups including the control group,aspirin positive control group and three groups respectively administered with rose essential oil at the doses of 25,50 mg/kg and 100 mg/kg.After oral administration of aspirin or rose essential oil once daily for 3 consecutive days,the effect of rose essential oil on thrombosis were explored by arteriovenous shunt thrombosis method.Results: Rose essential oil could significantly inhibit platelet aggregation induced by ADP,A23187 or CaCl2 in vitro and the arteriovenous shunt thrombosis in vivo in a dose-dependent manner.These results demonstrated that rose essential oil had strong anti-platelet aggregation and anti-thrombosis activity in vitro and in vivo.

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