Efficacy of Ampicillin Suspension against Colibacillosis in Chicken

ZHU Hui-nan et al(Qingdao Agricultural University,Qingdao,Shandong 266109)

Ampicillin suspension;Colibacillosis;Antibacterial trials;Chicken

[Objective] The research aimed to evaluate the curative effect of Ampicillin suspension against the chicken infected by coliform,and provide basis for clinical rational drug use.[Methods]The curative effect of Ampicillin suspension was tested in preventing the colibacillosis in Kebao Chicken through in vitro and in vivo experiments,and was compared the result with Ampicillin soluble powder.[Results]Vitro test results showed that:the minimal inhibitory concentration of E.coli by Ampicillin suspension and Ampicillin soluble powder were 1 μg/ml and 4 μg/ml.Vivo antibacterial trials indicated that:the mortality of Ampicillin suspension groups were lower than positive control group obviously,the difference was significant(P<0.05-0.01).Compared the groups used Ampicillin Suspension and Ampicillin Soluble Powder,the cure rate and effective power were significantly increased,the mortality was significantly decreased,but there were no significant difference.Compared the groups used Ampicillin Suspension with the positive control group,the results in weight gain was significant difference(P<0.01);the treatment groups used Ampicillin Suspension with the negative control group were significant difference(P<0.05);the Ampicillin suspension groups and the Ampicillin Soluble Powder groups were significant difference(P<0.05).[Conclusions] The Ampicillin suspension could be used for prevention and treatment of colibacillosis in chickens,the best dose to prevention was 30 mg/L and the treatment dose was 90 mg/L.