Position: Home > Articles > Study of Pharmacokinetics and Bioavailability of Ampicillin Suspension in Fowl
China Animal Husbandry & Veterinary Medicine
2010,37
(6)
176-179
氨苄西林混悬液在鸡体内的药物动力学及其生物利用度研究
作 者：
刘志亮;余祖功;李丽杰;裴香玲;乔彦良;闫祥华;马凤龙
单 位：
南京农业大学;山东信得科技股份有限公司
关键词：
氨苄西林混悬液;药物动力学;消除半衰期;绝对生物利用度
摘 要：
作者对10%氨苄西林混悬液在靶动物-鸡体内的药物动力学及生物利用度进行了研究,结果表明,10%氨苄西林混悬液吸收迅速,达峰时间快,约0.89h即达峰值;消除半衰期较短,约2.5h;绝对生物利用度为35.27%,略高于氨苄西林溶液剂的绝对生物利用度(34.30%);氨苄西林混悬液在鸡口服给药后的生物等效性为109.8%。
译 名：
Study of Pharmacokinetics and Bioavailability of Ampicillin Suspension in Fowl
作 者：
LIU Zhi-liang1,YU Zu-gong2,LI Li-jie1,PEI Xiang-ling1,QIAO Yan-liang1,YAN Xiang-hua1,MA Feng-long1(1.Shandong Sinder Technology Corporation,Qingdao 266061,China;2.Nanjing Agricultural University,Nanjing 210095,China)
关键词：
Ampicillin suspension;wlimination half-life;absolute bioavailability;bioequivalence
摘 要：
This article studied the pharmacokinetics and bioavailability of 10% Ampicillin suspension in vivo of target animal-fowl.The result showed that the absorption of 10% Ampicillin suspension was quick;the reaching peak time was short,about 0.89 h;the elimination half-life was about 2.5 h;and the absolute bioavailability was 35.27%,lightly higher than the absolute bioavailability of Ampicillin solution(34.30%);the bioequivalence of 10% Ampicillin suspension with oral administration to fowl was 109.8%.
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