当前位置: 首页 > 文章 > 迟缓爱德华菌人工感染斑马鱼的致病性及组织病理学变化 畜牧与兽医 2011,43 (1) 23-26
Position: Home > Articles > The pathogenicity and histopathological changes of artificially infected zebrafish with Edwardsiella tarda Animal Husbandry & Veterinary Medicine 2011,43 (1) 23-26

迟缓爱德华菌人工感染斑马鱼的致病性及组织病理学变化

作  者:
彭国瑞;王成龙;王雪鹏;陆承平
单  位:
山东农业大学动物科技学院;南京农业大学动物医学院
关键词:
迟缓爱德华菌;斑马鱼;致病性;病理学
摘  要:
用迟缓爱德华菌真鲷分离株(E.t-CD)对斑马鱼进行人工感染试验,观察其发病、死亡以及相关病理学变化。结果表明,该菌对斑马鱼的半数致死浓度(LD50)为2.69×102 cfu/尾;感染发病鱼呈现岀血、溃疡、腹水、败血等症状;病理组织学检查以肝脏水肿变性,肝细胞萎缩、坏死、脱落;脾脏散在增生性结节、充血、水肿、淋巴细胞大量缺失等病变为主。结果表明,斑马鱼可作为研究迟缓爱德华菌致病性的动物模型。
译  名:
The pathogenicity and histopathological changes of artificially infected zebrafish with Edwardsiella tarda
作  者:
PENG Guo-rui1,WANG Cheng-long1,WANG Xue-peng1,2*,LU Cheng-ping1(1.College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China; 2.College of Animal Science & Technology,Shandong Agricultural University,Tai'an 271018,China)
关键词:
Edwardsiella tarda;zebrafish;pathogenicity;pathology
摘  要:
Clinical manifestations and pathological changes were observed after the zebrafish were artificially infected with Edwardsiella tarda strain CD(E.t-CD).The results showed that the median lethal dose(LD50) for zebrafish was 2.69×102 cfu/fish,and the infected fish showed bleeding,ulcers,ascites,sepsis and other symptoms.Histopathological observation showed that swelling degeneration,atrophy,necrosis and abscission in the liver cells;scattered hyperplastic nodules,congestion,edema and absence of lymphocyte in the spleen cells.The results indicated that the zebrafish could be used as the animal models for studying the pathogenicity of E.tarda.

相似文章

计量
文章访问数: 7
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊