Position: Home > Articles > Research Advances in Heterologous Expression of ClassⅡa Bacteriocins from Lactic Acid Bacteria
FOOD SCIENCE
2012,33
(5)
323-327
Ⅱa类乳酸菌细菌素的异源表达研究进展
作 者：
刘国荣;孙勇;李平兰
单 位：
北京市食品研究所;北京工商大学食品添加剂与配料北京高校工程研究中心食品风味化学北京重点实验室;中国农业大学食品科学与营养工程学院
关键词：
Ⅱa类乳酸菌细菌素;单核细胞增生李斯特菌;异源表达
摘 要：
Ⅱa类乳酸菌细菌素由于其对单核细胞增生李斯特菌的强烈抑菌活性,已成为天然食品防腐剂研究与开发的热点。但是受生物合成调控系统控制,天然细菌素的产量往往很低而且提取过程较为复杂,很难满足相关研究和实际应用的需求。为此,许多研究者进行过Ⅱa类细菌素的异源表达研究,本文对该类细菌素在大肠杆菌、乳酸菌以及酵母菌中的异源表达研究作较为全面系统的综述,并指出目前存在的主要问题及今后的研究方向。
译 名：
Research Advances in Heterologous Expression of ClassⅡa Bacteriocins from Lactic Acid Bacteria
作 者：
LIU Guo-rong1,3,SUN Yong2,LI Ping-lan3,(1.Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients,Beijing Key Laboratory of Flavor Chemistry,Beijing Technology and Business University,Beijing 100048,China;2.Beijing Food Research Institute,Beijing 100162,China;3.College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China)
关键词：
class Ⅱa bacteriocins;Listeria monocytogenes;heterologous expression
摘 要：
Class Ⅱa bacteriocins from lactic acid bacteria,which have a strong antibacterial activity against Listeria monocytogenes,have become a hot topic in the research and development of natural preservatives.However,the bacteriocins are always produced at very low levels under the control of the biosynthesis regulatory system and their extraction is very complex,which makes it very difficult to meet the demands for relevant studies and practical applications.For this reason,the heterogenous expression of class Ⅱa bacteriocins has been widely studied in recent years.This paper summarizes a comprehensive systematic review of recent studies on the heterogenous expression of the bacteriocins in E.coli,lactic acid bacteria and yeast and points out the current main problems and future research directions.
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