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Position: Home > Articles > Isolation and Activity Study of Nature Taurine in Scapharca subcrenata Journal of Anhui Agricultural Sciences 2012,40 (17) 114-115

毛蚶中天然牛磺酸的提取和活性研究

作  者:
徐艳;宋成芝;孙雪萍;张向云;童万平
单  位:
昭通师范高等专科学校化学系;中国科学院广州地球化学研究所;广西海洋研究所
关键词:
毛蚶;牛磺酸;提取;细胞毒性
摘  要:
[目的]提取和纯化毛蚶(Scapharca subcrenata)中的天然牛磺酸,并对其活性进行研究。[方法]采用薄层色谱法(TLC)对提取的牛磺酸纯度进行分析,并对其结构用红外光谱(IR)和核磁共振波谱(NMR)进行鉴定,然后对其细胞毒活性进行检测。[结果]毛蚶富含牛磺酸,对人白血病细胞HL-60、肝癌细胞SMMC-7721、肺癌细胞A-549、乳腺癌细胞MCF-7和结肠癌细胞SW480没有明显的细胞毒活性。[结论]该研究为天然牛磺酸的开发和利用提供了依据。
译  名:
Isolation and Activity Study of Nature Taurine in Scapharca subcrenata
作  者:
XU Yan et al(Guangxi Institute of Oceanology,Guangxi Key Laboratory of Marine Biotechnology,Beihai,Guangxi 536000)
关键词:
Scapharca subcrenata;Taurine;Isolation;Cytotoxicity
摘  要:
[Objective] The aim was to isolate and purify taurine in Scapharca subcrenata,and its activity was studied.[Method] The purity of isolated taurine was analyzed by TLC,and its structure was determined by IR and NMR,and then its cytotoxicity in vitro was detected.[Result] The results showed that the yield of taurine in S.subcrenata was high,and there were no significant cytotoxic activities against human leukemia cell line HL-60,hepatocarcinoma cancer cell line SMMC-7721,lung cancer cell A-549,human breast cancer cell line MCF-7 and colorectal cancer cell line SW480.[Conclusion] The study provides a basis for development and utilization of nature taurine.

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