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当前位置: 首页 > 文章 > 汉族和藏族婴儿肠道微生物群落结构和多样性分析（英文） 食品科学 2019 (24) 128-135
Position: Home > Articles > Structural Segregation of the Gut Microbiome between Chinese Han and Tibetan Infants FOOD SCIENCE 2019 (24) 128-135

汉族和藏族婴儿肠道微生物群落结构和多样性分析（英文）

作  者：
张秋雪;尚佳萃;朱德全;朱宗涛;万峰;贾芳芳;孙思睿;孟祥晨
单  位：
佳木斯大学理学院;东北农业大学乳品科学教育部重点实验室食品安全与营养协同创新中心
关键词：
婴儿;肠道微生物;民族;共同进化
摘  要：
为了解民族因素对婴儿的影响,对中国汉族和藏族母乳喂养的健康婴儿粪便微生物菌群进行研究。通过16SrRNA高通量测序技术,发现两组粪便微生物的组成存在差异。在门水平上,汉族婴儿的放线菌门相对丰度较高,而藏族则以厚壁菌门为主,且两组间的厚壁菌门差异显著(P<0.05)。基于UniFrac的非加权和加权的主坐标分析表明汉族和藏族婴儿肠道微生物群结构有显著性差异。此外,偏最小二乘判别分析显示两组间微生物明显分离。研究表明,肠道微生物群可以在不同民族的婴儿之间进行区别,从而扩展人类及其共生肠道微生物群共同进化的认识。
译  名：
Structural Segregation of the Gut Microbiome between Chinese Han and Tibetan Infants
作  者：
ZHANG Qiuxue;SHANG Jiacui;ZHU Dequan;ZHU Zongtao;WAN Feng;JIA Fangfang;SUN Sirui;MENG Xiangchen;Key Laboratory of Dairy Science, Ministry of Education, Synergetic Innovation Center of Food Safety and Nutrition,Northeast Agricultural University;College of Science, Jiamusi University;
关键词：
infant;;gut microbiota;;ethnicity;;co-evolution
摘  要：
Ethnicity is considered as one of the major driving forces to shape the human gut microbiota, but how the gut microbiota evolves in population with disparate ethnic backgrounds since infants are born remains still unclear. Thus, this study aimed to understand the impact of ethnicity on infants. We investigated the fecal microbiota of healthy infants(3–6 months old, with breast feeding) from the Chinese Han and Tibetan ethnic groups(n = 10 for each group). By using highthroughput 16 S rRNA gene sequencing analyses, we found some differences in fecal microbiota composition between the two groups. At the phylum level, the Han infants harbored higher relative abundance of Actinobacteria, whereas Firmicutes was more predominant in the Tibetans. A significant difference at the phylum level existed in Firmicutes(P < 0.05) between the two groups. Bifidobacterium and Escherichia-Shigella were the first and second major genera in both groups, respectively. There was a clear separation between the groups by principal coordinates analysis(PCoA) based on unweighted and weighted UniFrac distance. Moreover, partial least squares-discriminant analysis(PLS-DA) showed that the infant gut microbiome was segregated according to ethnicity. Taken together, our findings suggest that the gut microbiota could be differentiated between infants from distinct ethnic origins, and this expanded our knowledge of the co-evolution of human hosts and their symbiotic gut microbiota.

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