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Position: Home > Articles > Molecular mechanisms of juvenile hormone action Acta Entomologica Sinica 2008,51 (9) 82-86

保幼激素的分子作用机制

作  者:
刘影;胜振涛;李胜
单  位:
中国科学院上海生命科学研究院植物生理生态研究所
关键词:
保幼激素;蜕皮激素;保幼激素受体;Met;USP;蛋白激酶C
摘  要:
蜕皮激素(ecdysteroids,Ecd)和保幼激素(juvenile hormone,JH)是调控昆虫发育和变态的两种最为重要的昆虫激素。尽管Ecd的分子作用机制已经相当明了,但是,因为迄今为止还没有成功地鉴定出JH受体,人们对JH的分子作用机制还了解甚少。本文从三个方面较为详尽地介绍了近年来JH分子作用机制的相关研究进展:1)JH和Ecd在分子水平上相互作用,JH可以通过改变或者抑制Ecd信号来调控昆虫的发育和变态;2)JH核受体的两个候选基因为Met和USP;3)JH还可以通过膜受体和蛋白激酶C传导信号。
译  名:
Molecular mechanisms of juvenile hormone action
作  者:
LIU Ying,SHENG Zhen-Tao,LI Sheng(Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200032,China)
关键词:
Juvenile hormone;ecdysteroids;juvenile hormone receptor;methoprene-tolerant protein(Met);ultraspiracle(USP);protein kinase C(PKC)
摘  要:
Ecdysteroids(Ecd)and juvenile hormones(JH)play critical roles in regulating insect development and(metamorphosis.Though the molecular mechanisms of Ecd action are well understood now,those of JH action,in contrast,are still poorly known mostly because the JH receptor has not been successfully identified yet.In this review,we described three aspects of recent progresses in molecular mechanisms of JH action.1.JH and Ecd cross-talk with each other at the molecular level.JH modulates or suppresses Ecd signal to regulate insect development and metamorphosis.2.Met and USP are two potential JH nuclear receptors.3.JH also transduces signal via membrane receptor and protein kinase C.

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