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当前位置: 首页 > 文章 > 翻白草水提液对离体肝细胞糖代谢影响的研究 食品科学 2005,26 (5) 229-232
Position: Home > Articles > Study on Effect of Water Extracts of Discolored Cinquefoil Herb on Metabolism of Glucose of Mice Liver Cell in vitro FOOD SCIENCE 2005,26 (5) 229-232

翻白草水提液对离体肝细胞糖代谢影响的研究

作  者：
张红芝;何计国;陈金兰;刘宗林
单  位：
北京市食品研究所;中国农业大学食品科学与营养工程学院
关键词：
翻白草;细胞培养;胰岛素抵抗;降血糖
摘  要：
本实验研究了翻白草水提液对离体肝细胞糖代谢的影响。结果表明:翻白草水提液不仅能显著促进胰岛素抵抗原代小鼠肝细胞的葡萄糖代谢(p<0.05),而且还能显著提高正常小鼠肝细胞对葡萄糖的吸收和利用(p<0.01)。实验表明含有5×10-7mol/L胰岛素的DMEM培养液可成功制备胰岛素抵抗原代小鼠肝细胞模型;固形物含量为0.9mg/ml的翻白草水提液能更好的促进离体肝细胞对葡萄糖的吸收和利用。
译  名：
Study on Effect of Water Extracts of Discolored Cinquefoil Herb on Metabolism of Glucose of Mice Liver Cell in vitro
作  者：
ZHANG Hong-zhi 1 ,HE Ji-guo 1 ,CHEN Jin-lan 1 ,LIU Zong-lin 2 (1.College of Food Science and Nutritional Engineering, China Agricultural University,Beijing 100083, China; 2.Beijing Food Research Institute,Beijing 100076,China)
关键词：
Discolor cinquefoil herb;cell culture;insulin-resistant;metabolism of glucose
摘  要：
This paper studyed the efficacy of water extracts of Discolored Cinquefoil Herb on boosting metabolism of glucose of mice liver cell inv itro. The results showed that water extracts of Discolored Cinquefoil Herb could increase the ability of glucose intakea ndm etabolismo f thei nsulin-resistantm icel iver cellsi n vitro( p<0.05).F urthermore,t he watere xtractsc ouldh elpn ormal micel iverc ells in vitro make better use of glucose (p<0.01).T he resultsi ndicatedt hatl iver cellse xposed to5 ×10 -7 mol/L insulin for 16h were able to induce a state of insulin-resistance. And the concentration of 0.9mg/ml water extracts of Discolor Cinquefoil Herb had the strongest capability of increasing metabolism of glucose.

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