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当前位置: 首页 > 文章 > 虫生真菌Isaria cateniannulata次级代谢产物及抗肿瘤活性研究 安徽农业科学 2019 (3) 196-198
Position: Home > Articles > Study on Secondary Metabolites and Antitumor Activities of Entomopathogenic Fungus Isaria cateniannulata Journal of Anhui Agricultural Sciences 2019 (3) 196-198

虫生真菌Isaria cateniannulata次级代谢产物及抗肿瘤活性研究

作  者：
石佩星;李晓芳;解飞翔;张炳文;陈凤丽;李宝库;罗都强
单  位：
河北大学药学院;河北大学生命科学学院
关键词：
虫生真菌;环链棒束孢;倍半萜类化合物;抗肿瘤活性;结构鉴定
摘  要：
[目的]对虫生真菌环链棒束孢(Isaria cateniannulata)的次级代谢产物进行分离并研究其抗肿瘤活性。[方法]采用溶剂萃取、硅胶柱色谱、凝胶Sephadex LH-20等方法进行分离纯化,根据理化性质和波谱技术对分离得到的化合物进行结构鉴定,利用MTT法对化合物的抗肿瘤活性进行测试。[结果]从虫生真菌Isaria cateniannulata中共分离得到8个化合物,分别为β-麦角甾醇、豆甾-4-烯-3-酮、5α,8β-过氧-(22E,24R)-麦角甾-6,22-二烯3β-醇、4-methyl-5,6-dihydro-2H-pyran-2-one、(R)-甲羟戊酸内酯、对羟基苯甲醛、β-石竹烯和石竹烯氧化物。除化合物4外,其余化合物均是从该种中首次分离得到。抗肿瘤结果显示,化合物7、8对肿瘤细胞具有一定的抑制能力。[结论]该研究为新的抗肿瘤药物开发方面提供了广阔空间。
译  名：
Study on Secondary Metabolites and Antitumor Activities of Entomopathogenic Fungus Isaria cateniannulata
作  者：
SHI Pei-xing;LI Xiao-fang;XIE Fei-xiang;College of Life Science,Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education,Hebei University;College of Pharmaceutical Sciences,Key Laboratory of Pharmaceutical Quality Control of Hebei Province,Hebei University;
单  位：
SHI Pei-xing%LI Xiao-fang%XIE Fei-xiang%College of Life Science,Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education,Hebei University%College of Pharmaceutical Sciences,Key Laboratory of Pharmaceutical Quality Control of Hebei Province,Hebei University
关键词：
Entomogenous fungus;;Isaria cateniannulata;;Sesquiterpenoids;;Anti-tumor activity;;Structural identification
摘  要：
[Objective] The research aimed to isolate the secondary metabolites of entomogenous fungus Isaria cateniannulata and to study their anti-tumor activity. [Method]Compounds were isolated by the methods of solvent extraction,silica gel column chromatography,sephadex LH-20,and then the structures were identified by physicochemical properties and spectrum technology. The anti-tumor activity of the isolated compounds was tested using MTT method. [Result]Eight compounds were isolated from the entomopathogenic fungus Isaria cateniannulata,which were β-ergosterol,myristate-4-en-3-one,5α,8β-peroxy-( 22 E,24 R)-ergoside-6,22-diene 3β-alcohol,4-methyl-5,6-dihydro-2 H-pyran-2-one,( R)-mevalonate,p-hydroxybenzaldehyde,β-caryophyllene and caryophyllene oxid. All the compounds except compound 4 were firstly isolated from Isaria cateniannulata.The anti-tumor result indicated that compounds 7 and 8 presented a certain inhibitory ability to tumor cells. [Conclusion]The study provides a broad space for new anti-cancer drug development.

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