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当前位置: 首页 > 文章 > 革兰阴性菌对多黏菌素的耐药性及其机制研究进展 动物医学进展 2013,34 (2) 83-86
Position: Home > Articles > Advance in Polymyxin Resistence and Mechanisms in Gram-negative Bacteria Progress in Veterinary Medicine 2013,34 (2) 83-86

革兰阴性菌对多黏菌素的耐药性及其机制研究进展

作  者：
魏蕊蕊;张纯萍;邹明;徐士新;刘灿
单  位：
青岛农业大学动物科技学院;中国兽医药品监察所
关键词：
革兰阴性菌;多黏菌素;耐药性
摘  要：
多黏菌素是一种多肽类抗生素,对革兰阴性菌具有强大的抗菌作用,在兽医临床上主要用作饲料添加剂以促进畜禽的生长。近些年,超级耐药菌不断出现,治疗有效的药物越来越少,多黏菌素作为治疗多重耐药革兰阴性菌感染的"最后选择"而日益受到重视。随着多黏菌素的使用,目前已经出现了对多黏菌素耐药的革兰阴性菌。为了解革兰阴性菌对多黏菌素的耐药性以及耐药机制,论文对多黏菌素的作用机理、耐药性和耐药机制等的研究进展进行了综述,以为临床合理使用抗菌药物、抑制革兰阴性菌对多黏菌素耐药性的发生发展及研发新型抗菌药物等提供资料。
译  名：
Advance in Polymyxin Resistence and Mechanisms in Gram-negative Bacteria
作  者：
WEI Rui-rui1,ZHANG Chun-ping2,ZOU Ming1,XU Shi-xin2,LIU Can2,3(1.College of Animal Science And Veterinary Medicine,Qingdao Agricultural University,Qingdao,Shandong,266109,China; 2.China Institute of Veterinary Drug Control,Beijing,100081,China; 3.College of Veterinary Medicine,China Agricultural University,Beijing,100083,China)
关键词：
Gram-negative bacteria;polymyxin;drug resistance
摘  要：
Polymyxins are a kind of polypeptide antibiotics which are significantly effective for the treatment of infection caused by multidrug-resistant Gram-negative bacteria.It has been mainly used as a food additive for promoting the growth of livestocks.During the past few years,the importance of polymyxins were emphasized increasingly by veterinarians.Polymyxins are also considered as the "last hope" for coping with the appearance of multidrug-resistant Gram-negative bacteria.Gram-negative bacteria with the resistance to polymyxins are arising due to the extensive application of polymyxins.The polymyxins' function mechanism,the resistance to polymyxins and the resistant mechanism of polymyxins were reviewed in this paper to provide theoretical support to clinical application of antimicrobial agents,inhibition of the occurrence and development of Gram-negative bacteria resistance to polymyxins,and the development of new types of antibacterial drugs.

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