当前位置: 首页 > 文章 > 顶复门原虫3-磷酸甘油醛脱氢酶功能及其应用研究进展 中国畜牧兽医 2012,39 (1) 78-81
Position: Home > Articles > Research Advances on the Function and Application of Glyceraldehydes-3-phosphate Dehydrogenase in Apicomplexa China Animal Husbandry & Veterinary Medicine 2012,39 (1) 78-81

顶复门原虫3-磷酸甘油醛脱氢酶功能及其应用研究进展

作  者:
廖申权;戚南山;吴彩艳;吕敏娜;袁建丰;余劲术;孙铭飞
单  位:
广东省农业科学院兽医研究所广东省兽医公共卫生公共实验室
关键词:
顶复门原虫;3-磷酸甘油醛脱氢酶;药物靶标
摘  要:
糖酵解途径广泛存在于各类生物中,是顶复门原虫的主要供能方式。3-磷酸甘油醛脱氢酶是糖酵解途径的重要酶,与顶复门原虫的生存密切相关,可以作为抗寄生虫药物研发的重要靶标。文章主要从顶复门原虫糖酵解途径、3-磷酸甘油醛脱氢酶的基因分析、作用机理及应用等方面进行综述。
译  名:
Research Advances on the Function and Application of Glyceraldehydes-3-phosphate Dehydrogenase in Apicomplexa
作  者:
LIAO Shen-quan,QI Nan-shan,WU Cai-yan,LV Min-na,YUAN Jian-feng,YU Jin-shu,SUN Ming-fei(Guangdong Common Lab of Veterinary Public Health,Institute of Veterinary Medicine, Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China)
关键词:
Apicomplexa;glyceraldehyde-3-phosphate dehydrogenase(GAPDH);drug target
摘  要:
Glycolysis exists in various organisms.It is the major energetic process in apicomplexan parasites.Glyceraldehyde-3-phosphate dehydrogenase(GAPDH) plays an important role in glycolysis,which closely related to the survival of parasites.GAPDH is proposed to be a potential target for antiparasitic drugs.This review will focus on glycolysis and the genetic analysis,mechanism and application of glyceraldehydes-3-phosphate dehydrogenase in Apicomplexa.

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