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当前位置: 首页 > 文章 > 盐酸氯苯胍在红笛鲷体内的药代动力学及残留消除规律 广东海洋大学学报 2016,36 (6) 33-37
Position: Home > Articles > Pharmacokinetics and Elimination Regularity of Robenidine Hydrochloride Residues in Luthjanus sanguineus Journal of Guangdong Ocean University 2016,36 (6) 33-37

盐酸氯苯胍在红笛鲷体内的药代动力学及残留消除规律

作  者：
汤菊芬;蔡佳;黄瑜;廖建萌;黄月雄;简纪常
单  位：
湛江市食品药品检测所;广东海洋大学水产学院
关键词：
盐酸氯苯胍;红笛鲷;药代动力学;药物残留;消除
摘  要：
在水温(28±2)℃、盐度28条件下,将盐酸氯苯胍(Robenidine hydrochloride,ROBH)按30 mg/kg的剂量口灌红笛鲷(Luthjanus sanguineus),用HPLC-MS/MS法研究ROBH在红笛鲷体内的药代动力学和残留消除规律。结果表明:单剂量口灌给药后,红笛鲷血浆中ROBH的药时数据符合一级吸收二室模型,药物在血浆中的达峰时间t_p为1.79 h,血药浓度峰值C_(max)为211.38μg/L,药时曲线下面积(AUC_(0-∞))为5 229.16μg/(L·h),消除半衰期(t1/2β)为46.99 h。ROBH在红笛鲷其他组织中分布较广,消除速度较慢,肌肉、肝脏和肾脏的C_(max)分别为37.58、863.02、1 063.24μg/kg,t_p均为1.5 h,AUC0-∞分别1 017.03、20 841.20、30 743.04μg/(kg·h);t1/2β分别为26.35、14.05和24.31 h。连续5 d口灌给药后,红笛鲷血浆、肌肉、肝脏和肾脏中的药物消除半衰期t1/2分别为46.14、36.11、28.62、26.92 h。以10μg/kg为最高残留限量,肌肉作为食用靶组织,在本试验条件下,建议休药期不少于7 d。
译  名：
Pharmacokinetics and Elimination Regularity of Robenidine Hydrochloride Residues in Luthjanus sanguineus
作  者：
TANG Ju-fen;CAI-jia;HUANG Yu;LIAO Jian-meng;QIN Qing-ying;HUANG Yue-xiong;JIAN Ji-chang;Fisheries College, Guangdong Ocean University;Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animals;Zhanjiang Food and Drug Inspection Institute;
关键词：
Robenidine hydrochloride;;Luthjanus sanguineus;;pharmacokinetics;;drug residues;;elimination
摘  要：
The pharmacokinetics and elimination regularity of Robenidine hydrochloride(ROBH) residues were investigated in tissues of Luthjanus sanguineus with a 30 mg/kg body weight after oral administration at the water temperature of(28±2) ℃ and salinity of 28 by HPLC-MS/MS method. The results showed that the date of ROBH concentration-time in plasma of L. sanguineus could be described as a two-compartment model with first-order absorption. The peak time(t_p) was 1.79 h, and the maximum concentration(C_(max)) was 211.38 μg/L, the area under the concentration-time curve(AUC_(0-∞)) was 5 229.16 μg/(L·h), and the elimination hal-life(tl/2β) of plasma was 46.99 h. ROBH has a wide distribution in organizations of L. sanguineus and eliminated slowly. The C_(max) in muscle, liver and kidney were 37.58, 863.02 and 1 063.24 μg/kg; t_p were all 1.50 h; AUC_(0-∞) were 1 017.03, 20 841.20 and 30 743.04 μg/(kg·h); tl/2β were 26.35, 14.05 and 24.31 h, respectively. After oral administration continuous with 30 mg/kg dose for 5 days, the t1/2 in plasma, muscle, liver and kidney of L. sanguineus were 46.14, 36.11, 28.62, and 26.92 h, respectively. If the maximum residue limits(MRL) is 0.01 mg/kg and the muscles as the edible target tissue, the withdraw period should not be less than 7 days under this experiment condition.

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