当前位置: 首页 > 文章 > 辣木叶提取物降低高尿酸血症小鼠尿酸水平及机理研究 安徽农业科学 2017 (17) 108-109+112
Position: Home > Articles > Study on Extract of Moringa oleifera Leaves Reducing the Level of Uric Acid in Hyperuricemia Mice and Its Mechanism Journal of Anhui Agricultural Sciences 2017 (17) 108-109+112

辣木叶提取物降低高尿酸血症小鼠尿酸水平及机理研究

作  者:
梁文娟;和劲松;田洋;赵德锟;王洪玲
单  位:
云南农业大学食品科技学院;江西中医药大学中药资源与民族药研究中心
关键词:
辣木叶;高尿酸血症;尿酸水平;机理
摘  要:
[目的]研究辣木叶醇提物对血清尿酸(UA)、肌酐(Cre)、血尿素氮(Bun)、腺苷脱氨酶(ADA)以及肝脏黄嘌呤氧化酶(XOD)的影响。[方法]连续7 d灌胃给予辣木叶醇提物和别嘌呤醇(0.01 g/kg),诱导小鼠产生高尿酸血症,对比各组小鼠血清中UA、Cre、Bun、XOD和ADA的含量变化。[结果]与模型组比较,辣木叶提取物的低、中、高剂量组(1.0、2.0、4.0 g/kg)均可降低高尿酸血症小鼠UA、Cre、Bun、ADA、XOD的水平。[结论]辣木叶醇提物具有降尿酸作用,抑制XOD活性是其降低高尿酸血症小鼠血清尿酸水平的机制之一。
译  名:
Study on Extract of Moringa oleifera Leaves Reducing the Level of Uric Acid in Hyperuricemia Mice and Its Mechanism
作  者:
LIANG Wen-juan;HE Jin-song;TIAN Yang;WANG Hong-ling;College of Food Science and Technology,Yunnan Agricultural of University;Research Center for the Resourcing of Traditional Chinese Medicine and Minority Medicine,Jiangxi University of Traditional Chinese Medicine;
关键词:
Moringa oleifera leaves;;Hyperuricemia;;Level of uric acid(UA);;Mechanism
摘  要:
[Objective] The research aimed to study the effect of M. oleifera leave extract( MOLE) on the level of serum uric acid( UA),creatinine( Cre),blood usea nitrogen( Bun),adenosine deaminase( ADA) and liver xanthine oxidase( XOD). [Method]Intragastric administration of MOLE( 1. 0,2. 0,4. 0 g/kg) and allopurinol( 0. 01 g/kg) for 7 days,the level of UA,Cre,XOD and Bun in hyperuricemia mice induced by potassium oxonate was respectively analyzed.[Result]Compared with model group,each dosage group could degrade the levels of serum UA,Cre,Bun,ADA and XOD activities in hyperuricemia mice.[Conclusion]The MOLE could obviously reduce the level of serum uric acid,and the effect is related to its inhibition of hepatic XOD activities.

相似文章

计量
文章访问数: 13
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊