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当前位置: 首页 > 文章 > 小花棘豆小鼠亚急性中毒脾脏组织结构观察及“棘毒净”效果初探 新疆农业大学学报 2010,33 (1) 57-60
Position: Home > Articles > Preliminary Discussion on Organizational Structure of Spleen of Mouse with Sub-acute Poisoning Caused by Oxytropis and the Effect of Detoxification by Jidujing Journal of Xinjiang Agricultural University 2010,33 (1) 57-60

小花棘豆小鼠亚急性中毒脾脏组织结构观察及“棘毒净”效果初探

作  者：
米克热木·沙衣布扎提;斯坎达尔·买合木提;高超;宋丽
单  位：
新疆农业大学动物医学学院
关键词：
小花棘豆;亚急性中毒;脾脏组织结构;棘毒净
摘  要：
将42只昆明系小鼠随机分为3个小花棘豆中毒组、3个解毒组(小花棘豆添加量分别为日粮的5%,10%,20%)和一个同期对照组,进行为期15 d的亚急性毒性试验。结果表明,脾脏脏器系数呈现高剂量萎缩,低剂量增大现象。组织学观察,20%中毒组脾脏静脉扩张充血,周围组织有出血,脾结构尚完整,个别区域出血性浸润,使淋巴滤泡不完整;10%中毒组脾脏有明显出血,脾结构完整;5%中毒组脾脏有少量出血,脾结构完整。解毒剂有一定保护作用。
译  名：
Preliminary Discussion on Organizational Structure of Spleen of Mouse with Sub-acute Poisoning Caused by Oxytropis and the Effect of Detoxification by Jidujing
作  者：
Mikeremu·Shayibuzhati,Sikandaer·Maihemuti,GAO Chao,SONG Li (College of Animal Medicine,Xinjiang Agricultural University,Urumqi 830052,China)
关键词：
oxytropis;;sub-acute poisoning;;the organizational structure of the spleen;;Jidujing
摘  要：
42 rats from Kunming species were randomly divided into 3-poisoning(Oxytropis glabra DC) groups,3 detoxification groups(diet of 5%,10%and 20%) and a control group,a 15-day sub-acute poisoning test was conducted.The results showed that the coefficient of spleen organ shrinked in the high-dose and increased in low-dose through the factor analysis,observation by histological showed that,in the 20% of the poisoning group,there are the spleen vein congestive expansionand hemorrhage around the organization, the structure of the spleen is still complete,hemorrhagic infiltration occurres in individual region,so that the lymphoid follicles is incomplete;the spleen hemorrhages obviously happens in the 10%of the poisoning group;there is a small amount of hemorrhage in the 5%of the poisoning group.The group of the antidote have a certain protective effection.

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