中国农业科学院农业信息研究所 中国农学会
Agricultural Information Institute of CAAS China Association of Agricultural Science Societies
En
Ch
中国农业科学院农业信息研究所 中国农学会 主办

AI检索

订阅

返回顶部
当前位置: 首页 > 文章 > 黄牛FSHR基因的生物信息学分析 甘肃农业大学学报 2012,47 (4) 13-19
Position: Home > Articles > Bioinformatics analysis of cattle FSHR gene Journal of Gansu Agricultural University 2012,47 (4) 13-19

黄牛FSHR基因的生物信息学分析

作  者：
王明亮;陈鹏;郝明超;高旭东;刘犇;余四九
单  位：
甘肃农业大学动物医学院
关键词：
FSHR基因;黄牛;生物信息学;繁殖性状
摘  要：
利用生物基因组学数据库,对黄牛FSHR基因进行生物信息学分析,以预测FSHR基因编码产物的理化性质、结构与功能,同时构建FSHR同源系统进化树.结果表明:FSHR基因编码产物为疏水性跨膜蛋白,具有明显的信号肽,其切割位点位于17～18位的氨基酸之间,二级结构主要以α-螺旋与无规则卷曲为主,并主要在质膜中发挥生物学作用,跨膜区域分为跨膜域、胞外域和胞内域3个部分.序列分析表明,FSHR编码产物可能具有离子通道、运载体、受体、信号转导和阳离子通道等功能,在离子跨膜与信号传递过程中发挥重要作用,并对黄牛的激素调节有影响.FSHR基因编码产物系统进化树表明,黄牛FSHR与水牛、成都麻羊、绵羊等物种FSHR遗传距离较近,具有高度同源性.
译  名：
Bioinformatics analysis of cattle FSHR gene
作  者：
WANG Ming-liang,CHEN Peng,HAO Ming-chao,GAO Xu-dong,LIU Ben,YU Si-jiu(College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730070,China)
关键词：
follicle stimulating hormone receptor(FSHR) gene;cattle;bioinformatics;reproductive traits
摘  要：
This study aimed to analyze the bioinformatics analysis of FSHR gene in Bos taurus with genomics database.The physicochemical characteristics,structures and functions of B.taurus FSHR gene coding product were predicted and analyzed.Meanwhile,the phylogenetic tree of FSHR and related proteins was constructed.The results showed that FSHR gene coding product was hydrophobic transmembrane protein,which had obvious signal peptide,and the cleavage site of the signal peptide was between position 17 and 18.The secondary structure was primarily composed of alpha helix and random coil,and the biological effects of FSHR were performed in the plasma membrane.And the transmembrane segments composed of extracellular domain,transmembrane domain and intracellular domain.Sequence analysis indicated that this gene coding product might involve ion channel,transporter,receptor,signal transducer,cation channel,and played important roles in ion transmembrane and signal transduction,and the hormonal regulation of B.taurus was influenced.The FSHR of B.taurus and related proteins of Bubalus bubalis,Capra hircus,Ovis aries were close in the phylogenetic tree,which showed highly homology.

相似文章

导出引用
计量
文章访问数: 9
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊

友情链接Friendly link
农业信息研究所Agricultural information institute 农业智能知识服务平台Agricultural intelligent knowledge service platform 农业学术服务平台Agricultural Knowledge Service System 中国知网CNKI 维普网VIP 万方WANFANG DATA
联系我们Contact us

电话Tell：010-82109652-808

邮箱E-mail：agrijournal@caas.cn

服务Service
关于我们About us 意见建议Opinions and suggest
版权说明Copyright
单位：中国农业科学院农业信息研究所 中国农学会 © 2017中国农业科学院农业信息研究所 ICP备案号：京ICP备09089781号-46