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Position: Home > Articles > The Biological Effects Induced by Heavy Ion Radiation and Its Application in Life Science Biotechnology Bulletin 2018 (1) 67-78

重离子的辐射生物效应及其在生命科学中的应用

作  者：
贾蓉;苏锋涛;胡步荣
单  位：
中国科学院大学;复旦大学附属肿瘤医院肿瘤研究所;中国科学院重离子辐射生物医学重点实验室甘肃省空间辐射生物学重点实验室中国科学院近代物理研究所
关键词：
重离子;DNA团簇损伤;辐射诱变育种;重离子放射治疗
摘  要：
重离子是指重于元素周期表中2号元素氦并被电离的粒子。高能重离子因在其穿透物质的径迹上产生很强的局部电离,与传统的光子辐射(如X、γ射线)相比,会诱导更严重的辐射损伤生物效应。目前的机理研究显示,重离子辐射造成细胞DNA局部一到两个螺旋内出现多类型、多数量的损伤,即DNA团簇损伤。这种复杂的损伤影响DNA修复酶与DNA片段结合,进而影响修复,导致细胞死亡或产生不正确修复(即突变)。重离子辐射易引起突变的特征在植物与微生物诱变育种方面得到青睐。此外,重离子的细胞杀伤作用大,而且重离子具有倒转的剂量分布优势,将其用于癌症治疗,可使深部区域肿瘤细胞因高剂量辐射而被有效杀灭,而对周围组织因低剂量分布、相对危害较小,能实现精确靶向治疗,这被认为是最有前景的肿瘤放疗技术。对由重离子造成的DNA团簇损伤及其修复机制,以及两个重要修复途径的研究进展,进行了总结与深入分析。此外,我们还对重离子在辐射诱变育种和肿瘤治疗方面的应用进行了概要介绍,以期为从事重离子辐射生物学研究的人员理解DNA团簇损伤与修复机制及未来研究方向提供参考,促进对重离子辐射危害的评估与防护策略的建立、及其在生命科学中的良好应用。
译  名：
The Biological Effects Induced by Heavy Ion Radiation and Its Application in Life Science
作  者：
JIA Rong;SU Feng-tao;HU Bu-rong;CAS Key Laboratory of Heavy Ion Radiation Biology and Medicine,Key Laboratory of Space Radiobiology of Gansu Province,Institute of Modern Physics,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Fudan University Shanghai Cancer Center;
关键词：
heavy ions;;clustered DNA damage;;radiation-induced breeding;;heavy ion radiotherapy
摘  要：
The heavy ions are the ionized particles that are heavier than element He of second one in the element periodic table. Becauseof the strong local ionization on the pathway of penetration,the high-energy heavy ions induce the biological effects of more serious radiationdamage compared with the traditional photon radiation,such as X-rays or γ-. The researches onmechanism show that radiation by heavy ionsresults in multiple-type and multiple-number damages at one or two helixes of DNA,i.e.,the clustered DNA damage. The complex damagesimpede the binding of DNA repair enzyme with DNA segment and the consequent repairing of cells,resulting in the subsequent death of cells orimproper repair(i.e.,mutation). The characteristic of heavy ion radiation,easily inducing mutant,is popular in mutation breeding of plantand microorganism. In addition,due to the high cell killing capability and the advantage of inverted dose profile,the exact targeted therapy canbe achieved using heavy ions to treat tumor,because it delivers high doses of radiation to the deep regions of tumor cells to efficiently kill thembut causes relatively little damages to the surround tissues at low dose;thus,heavy ion beam is deemed a most promising technology of tumorradiotherapy. Here we review and deeply analyze the clustered DNA damage induced by heavy ions and its repairing mechanism,as well as theresearch advances on the 2 key repair pathways. Besides,we summarize the application of heavy ions in mutation breeding and cancer therapy.It is expected that this review may provide a convenience for researchers in radiation biology of heavy ion to understand clustered DNA damageand repair mechanisms,and culture the research direction for better estimating the risks of heavy ions to human health and setting up betterprotection strategy as well as the application in life science.

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