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当前位置: 首页 > 文章 > 山绿茶总黄酮对小鼠高脂血症模型调脂作用的研究 扬州大学学报(农业与生命科学版) 2009,30 (3) 68-70+74
Position: Home > Articles > Effect of hainan holly leaf total flavonoids on serum lipids based on hyperlipidemia mice Journal of Yangzhou University(Agricultural and Life Science Edition) 2009,30 (3) 68-70+74

山绿茶总黄酮对小鼠高脂血症模型调脂作用的研究

作  者：
魏菁;孙云
单  位：
扬州大学医学院;苏北人民医院
关键词：
小鼠;山绿茶总黄酮;高脂血症模型;调节血脂;形态结构
摘  要：
取ICR小鼠,饲喂高脂饲料,以建立高脂血症动物模型。用山绿茶总黄酮[300、1507、5 mg.(kg.d)-1]连续灌胃小鼠28 d,检测模型小鼠血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C);取肝脏制作切片,观察组织结构。结果表明:高脂血症模型小鼠的TC、TG、LDL-C含量明显高于正常组,HDL-C含量低于正常组;肝细胞中充满大量脂肪颗粒,细胞核呈固缩状。与模型组相比,山绿茶总黄酮高、中剂量均能一定程度降低血清LDL-C含量、提高HDL含量,差异极显著;山绿茶总黄酮能减少肝细胞质中脂肪颗粒及炎性细胞;部分细胞核无固缩现象,较模型组其形态结构有所改善。说明山绿茶总黄酮在一定程度上可降低高脂血症模型小鼠LDL-C含量、提高HDL含量,对血脂水平有调节作用;可改善肝细胞脂肪变性的形态结构。
译  名：
Effect of hainan holly leaf total flavonoids on serum lipids based on hyperlipidemia mice
作  者：
WEI Jing1,SUN Yun2 (1.Subei People's Hosp,Yangzhou 225001,China;2.Coll of Med,Yangzhou Univ,Yangzhou 225001,China)
关键词：
mice;hainan holly leaf total flavonoids;hyperlipidemia model;model modulate lipidemic;morphological structure
摘  要：
ICR mice were fed with high fat diet to establish hyperlipidemia model.Three dosage groups of hainan holly total flavonoids [300,150,75 mg·(kg·d)-1] were intragastric administrated for 28 d to detect triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C);Part of liver tissue was taken to make slices for observing liver's morphological structure.The data showed that levels of TC,TG,LDL-C of the normal group were remarkably higher than the normal group;and HDL-C level was lower than the normal group.Liver cells were full of fat particles and cell nucleus condensed.Compared with the model group,the high-mid-dose of hainan holly leaf total flavonoids both could significantly increase HDL-C level(P<0.01);Effect hainan holly leaf could decrease fat particles and Inflammatory cells in liver cytoplasm;part of cell nucleus don't condense.compared with the model group,it could improve cell nucleus's morphological structure.It is suggested that hainan holly leaf total flavonoias can decrease TG,LDL-C levels based on hyperlipidemia mice,to some extent and can improve lipoprotein level and Steatosis liver's morphological structure.

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