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Position: Home > Articles > Advance in Molecule Mechanism of Silkworm Sex Determination Science of Sericulture 2015 (5) 951-956

家蚕的性别决定分子机制研究进展

作  者:
郭东东;何石宝;唐文超;辛佳;朱勇
单  位:
西南大学生物技术学院
关键词:
家蚕;性染色体;性别决定基因;初始信号;剂量补偿
摘  要:
家蚕属于雌杂合型生物,性别决定于胚胎细胞染色体组中W染色体的有无,凡有W染色体的个体均为雌性,记为ZW型,雄性为ZZ型。深度测序发现位于家蚕W染色体的雌性决定基因Fem通过piRNA途径决定家蚕性别,位于Z染色体的Masc基因调控雄性胚胎的剂量补偿与决定Bmdsx的雄特异性剪切。本文主要介绍家蚕W染色体上Fem基因的发现及作为性别决定初始信号的作用,以及雄性Z染色体存在的剂量补偿机制和几个性别决定基因的级联调控关系等,并简要分析了该领域仍需要深入研究的内容。
译  名:
Advance in Molecule Mechanism of Silkworm Sex Determination
作  者:
Guo Dongdong;He Shibao;Tang Wenchao;Xin Jia;Zhu Yong;College of Biotechnology,Southwest University;
关键词:
Bombyx mori;;Sex chromosome;;Sex determining gene;;Primary signal;;Dosage compensation
摘  要:
The silkworm( Bombyx mori) is a female heterogametic organism. The sex of silkworm is determined by W chromosome in genome of embryonic cells. The female individual has W chromosome and its genotype is ZW,while that of male is ZZ. Deep sequencing indicated that female sex determining gene( Fem) in W chromosome controls the sex of silkworm by producing PIWI-interacting RNAs( piRNAs). In addition,Masc gene which locates on Z chromosome regulates both dosage compensation in male embryos and male-specific splicing of Bmdsx gene. In this article,we reviewed the discovery process of Fem gene and its role as the primary signal in sex determination of silkworm,the dosage compensation of Z chromosome in male embryos,and cascade regulation of several sex determining genes etc. What's more,this article briefly analyzed the issues in this area which need further in-depth researches.

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