当前位置: 首页 > 文章 > 氟苯尼考在日本鳗鲡和欧洲鳗鲡体内的药代动力学 安徽农业科学 2011,39 (36) 22341-22343+22517
Position: Home > Articles > Pharmacokinetics of Florfenicol in A.japonica and A.Anguilla Journal of Anhui Agricultural Sciences 2011,39 (36) 22341-22343+22517

氟苯尼考在日本鳗鲡和欧洲鳗鲡体内的药代动力学

作  者:
林茂;纪荣兴;陈政强;范红照;谢吉林
单  位:
集美大学水产学院
关键词:
氟苯尼考;日本鳗鲡;欧洲鳗鲡;药代动力学
摘  要:
[目的]研究氟苯尼考在日本鳗鲡和欧洲鳗鲡体内的药代动力学特征。[方法]氟苯尼考以混饲口灌方式给药,剂量为30 mg/kg,药时数据利用DAS软件进行药动学分析。[结果]日本鳗鲡和欧洲鳗鲡体内药动学的房室参数:吸收速率常数(Ka)分别为0.329和0.449 l/h,消除相半衰期(t1/2β)为44.266和12.690 h。非房室参数:药时曲线下面积(AUC0-∞)分别为257.099和285.945 mg.h/L,平均滞留时间(MRT0-∞)为18.370和14.227 h,半衰期(t1/2)为12.341和9.919 h,达峰浓度(Cmax)为15.92和20.39μg/ml,达峰时间(Tmax)均为4 h。[结论]建议在鳗鲡中使用氟苯尼考进行治疗时可采用30 mg/kg体重的剂量,给药间隔为12 h,即每天2次。
译  名:
Pharmacokinetics of Florfenicol in A.japonica and A.Anguilla
作  者:
LIN Mao et al (Fisheries College,Jimei University,Xiamen,Fujian 361021)
关键词:
Florfenicol;Anguilla japonica;Anguilla Anguilla;Pharmacokinetics
摘  要:
[Objective] To study the pharmacokinetic of florfenicol in A.japonica and A.Anguilla.[Method] 30mg/kg florfenicol was orally administrated,and the pharmacokinetics was analyzed using DAS software.[Result] Pharmacokinetics parameters were figured out using a two-compartmental and non-compartmental model.In A.japonica and A.Anguilla,absorption rate constant(K_a) were 0.329 and 0.449 1/h;half-life of drug during elimination phase(t_1/2β) were 44.266 and 12.690 h;area under the concentration-time curve(AUC_0-∞) were 257.099 and 285.945 mg·h/L;mean residence time(MRT_0-∞) were 18.370 and 14.227 h;half-life of drug(t_1/2) were 12.341 and 9.919 h;maximum concentrations(C_max) were 15.92 and 20.39 μg/ml,respectively;and time to maximum concentration(T_max) were both 4 h.[Conclusion] It was suggested that twice dose a day of 30 mg/kg body weight would be acceptable for treatment of eel with bacterial infections.

相似文章

计量
文章访问数: 25
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊