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Position: Home > Articles > Strategies for Increacing the Diversity of Microbial Secondary Metabolites Hubei Agricultural Sciences 2010,49 (12) 3207-3210

提高微生物次生代谢产物多样性的策略

作  者：
王开梅;张亚妮;张志刚;江爱兵;杨自文
单  位：
湖北省生物农药工程研究中心
关键词：
微生物;次生代谢产物;多样性;筛选方法;发酵;分子生物学
摘  要：
微生物次生代谢产物是新农药、新医药的重要来源。微生物次生代谢产物的多样性在一定程度上取决于微生物菌株的多样性,而在新的环境中取样,建立微生物新的筛选方法,可大大提高微生物菌株的多样性。通过培养基和培养条件的优化及提供不同种类的前体将会大大提高次生代谢产物的多样性。现代分子生物学技术则为沉默抗生素的挖掘、杂合抗生素的构建和微生物次生代谢产物的组合生物合成及不可培养微生物的次生代谢产物的研究提供了有力的工具。
译  名：
Strategies for Increacing the Diversity of Microbial Secondary Metabolites
作  者：
WANG Kai-mei,ZHANG Ya-ni,ZHANG Zhi-gang,JIANG Ai-bing,YANG Zi-wen (Hubei Biopesticide Engineering Research Centre, Wuhan 430064, China)
关键词：
microorganisms; secondary metabolites; diversity; selective isolation methods; fermentation; molecular biology
摘  要：
Microbial secondary metabolites are still one of the most important source for drug discovery and development. In this review, the authors focused on the strategies for increasing the diversities of microbial secondary metabolites. To a great extent, the diversity of microbial secondary metabolites depends on the diversity of microorganisms. To increase the diversity of the microorganisms, researchers should consider collecting samples from new environment, especially extreme environment, and establishing the selective isolation methods for rare microorganisms, and previously unculturable microorganisms. The production of microbial secondary metabolites depends on the composition of media, fermentation conditions and the supply of precursors. The studies on the physiological and biochemical properties of the microorganisms and the pathways of the biosynthesis of secondary metabolites will help the establishment of fermentation method and the precursor-directed biosynthesis of analogs of secondary metabolites. The progress in molecular biology not only fosters the finding of hybrid antibiotics and the discovery of the silent secondary metabolites through genomic mining, but also leads to the combinatorial biosynthesis of unnatural secondary metabolites. Metagenomics is a powerful tool to study the diversity of the unculturable microorganisms and mine the resources of secondary metabolites of unculturable microorganisms.

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