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Position: Home > Articles > Toxicity Study on Phytohemagglutinin from White kidney Bean Journal of Anhui Agricultural Sciences 2009,37 (28) 3639-3640

大白芸豆植物凝集素毒性研究

作  者:
王昌梅;张丽芬;杨明洁;张田;王敏康
单  位:
云南师范大学生命科学学院
关键词:
LD_(50);植物凝集素;急性毒性试验;昆明小白鼠
摘  要:
[目的]评价植物凝集素的急性毒性反应,为临床应用提供依据。[方法]小鼠腹腔单次注射不同剂量植物凝集素,观察其急性毒性状况和死亡情况。[结果]腹腔注射植物凝集素的结果是昆明小白鼠腹腔注射的LD_(50)是140.24 mg/kg,95%置信区间为125.19~178.91 mg/kg。[结论]云南丽江大白芸豆植物凝集素属于中等到低等毒性,使用时必须遵照安全剂量范围。
译  名:
Toxicity Study on Phytohemagglutinin from White kidney Bean
作  者:
WANG Chang-mei et al(School of Life Science,Yunnan Normal University,Kunming,Yunnan 650092)
关键词:
LD_(50);;Phytohemagglutinin;;Acute toxicity test;;Kunming mice
摘  要:
[Objective]The research aimed to evaluate the acute toxicity reaction of phytohemagglutinin(PHA) and provide a basis for clinical application.[Method]Kunming mice were injected through abdominal cavity one time with different dosage of PHA,observing their acute toxicity status and mortality situation.[Result]The results showed that the LD_(50) was 140.24 mg/kg,95%confidence interval was 125.19 - 178.91 mg/kg.[Conclusion]Because the PHA of white kidney bean from Yunnan Lijian was middle to low toxicity,it must be used in accordance with the safe dose range.

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