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当前位置: 首页 > 文章 > 植物乳杆菌Sc52联合牛蒡低聚果糖对2型糖尿病模型小鼠的治疗作用 食品科学 2015,36 (21) 214-220
Position: Home > Articles > Therapeutic Effect of Burdock Fructooligosaccharide Combined With Lactobacillus plantarum Sc52 on Type 2 Diabetic Mouse Model FOOD SCIENCE 2015,36 (21) 214-220

植物乳杆菌Sc52联合牛蒡低聚果糖对2型糖尿病模型小鼠的治疗作用

作  者：
栾畅;王宏伟;何忠梅;吕冠薇;段翠翠;赵玉娟;牛春华;李盛钰
单  位：
长春英平药业有限公司;吉林省农业科学院农产品加工研究所;长春医学高等专科学校教务处;吉林农业大学中药材学院
关键词：
植物乳杆菌;牛蒡低聚果糖;2型糖尿病;肠道菌群;肥胖
摘  要：
目的:研究植物乳杆菌(Lactobacillus plantarum)Sc52和牛蒡低聚果糖(burdock fructooligosaccharide,BFO)联合使用对2型糖尿病小鼠的治疗作用。方法:高脂饲料结合链脲佐菌素(streptozocin,STZ)建立2型糖尿病小鼠模型,分成6组,各组连续4周接受不同处理,实验结束后测定小鼠空腹血糖含量、血糖曲线下面积,血清中脂质、胰岛素和炎症因子水平等相关生化指标;分析小鼠粪便中短链脂肪酸含量及主要菌群数量。结果:Sc52+BFO组合能够抑制小鼠血清中总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、内毒素(endotoxin,ET)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)水平的升高,明显提升血清中高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、胰岛素(insulin,INS)水平;Sc52+BFO组合还能提高小鼠肠道中乙酸、丙酸、丁酸含量,降低乳酸含量;促进小鼠肠道中乳杆菌、双歧杆菌的生长,抑制肠球菌、肠杆菌、产气荚膜梭菌等有害微生物的生长,且Sc52+BFO组合治疗糖尿病的效果优于单独使用BFO和Sc52。结论:植物乳杆菌Sc52和BFO联合使用能够调节小鼠肠道菌群平衡、降低血糖血脂含量、抑制炎症因子表达,提高2型糖尿病小鼠胰岛素水平。
译  名：
Therapeutic Effect of Burdock Fructooligosaccharide Combined With Lactobacillus plantarum Sc52 on Type 2 Diabetic Mouse Model
作  者：
LUAN Chang;WANG Hongwei;HE Zhongmei;Lü Guanwei;DUAN Cuicui;ZHAO Yujuan;NIU Chunhua;LI Shengyu;Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences;Changchun Yingping Pharmaceutical Co.Ltd.;College of Traditional Chinese Medicine Materials, Jilin Agricultural University;Educational Administration Department, Changchun Medical College;
关键词：
Lactobacillus plantarum;;burdock fructooligosaccharide;;type 2 diabetes;;intestinal microflora;;obesity
摘  要：
Objective: To explore the therapeutic effect of burdock fructooligosaccharide(BFO) combined with Lactobacillus plantarum Sc52 on mice with type 2 diabetes induced by high-fat diet and streptozocin(STZ). Methods: C57BL/6J mice were intraperitoneally injected with STZ and fed with high-fat diet to establish a mouse model of type 2 diabetes. Then, Sc52, BFO and Sc52 combined with BFO were respectively given to mice by gavage for 4 consecutive weeks. The fasting blood glucose and tolerance dose were measured by Glucose Test Strips, serum lipids, INS, inflammatory factors and other biochemical indicators were also tested by kits, the contents of short-chain fatty acids were determined by gas chromatography and the major intestinal bacteria in feces were counted by coated plates. Results: L. plantarum Sc52 and BFO alone or in combination could inhibit the elevation of TC, TG, LDL-C, ET, TNF-α and IL-6 in serum and significantly increase HDL-C and INS levels in serum. The contents of acetic acid, propionic acid and butyric acid in intestine were raised but the content of lactic acid was decreased. L. plantarum Sc52 combined with BFO could promote the growth of Lactobacillus and Bifidobacterium, and inhibit the growth of Enterobacilli, Enterococcus, Clostridium perfringens and other harmful bacteria in the intestine of mice. The therapeutic effect of L. plantarum Sc52 combined with BFO was better than that either of them alone. Conclusion: L. plantarum Sc52 combined with BFO may improve insulin in a mouse model of type 2 diabetes by regulating the balance of intestinal flora in mice, decreasing the concentrations of blood glucose and serum lipids and inhibiting inflammatory cytokines.

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