当前位置: 首页 > 文章 > 蚕蛹蛋白多肽液抗肿瘤作用的实验研究 食品科学 2008,29 (11) 588-590
Position: Home > Articles > Anti-tumor Effects of Silkworm Pupa Protein Polypeptides in vitro and in vivo FOOD SCIENCE 2008,29 (11) 588-590

蚕蛹蛋白多肽液抗肿瘤作用的实验研究

作  者:
闫琦涛;曹柏营;昌友权
单  位:
吉林工程技术师范学院生物与食品工程学院;吉林工商学院食品工程系
关键词:
蚕蛹蛋白;多肽;抗肿瘤
摘  要:
通过动物及细胞实验研究蚕蛹蛋白多肽液的抗肿瘤作用。蚕蛹蛋白多肽质量浓度增加可使两肿瘤细胞存活率降低;肿瘤细胞总蛋白质含量随多肽浓度的增加逐渐降低(p<0.01),且在0.5~1.5g/L内呈剂量依赖性;对A549和Ketr-3的周期阻滞分别为G2~M期和G0~G1期;蚕蛹蛋白多肽液在150~600mg/g内,对小鼠S180和H22的抑瘤率分别达到28.72%~58.18%和27.64%~63.88%,明显延长EAC小鼠的生存时间。实验结果表明蚕蛹蛋白多肽液有显著的抗肿瘤作用。
译  名:
Anti-tumor Effects of Silkworm Pupa Protein Polypeptides in vitro and in vivo
作  者:
YAN Qi-tao1,CAO Bai-ying 2,CHANG You-quan2,*(1.College of Food Engineering,Jilin Institute of Industry and Commerce,Changchun 130062,China;2.College of Biology and Food Engineering,Jilin Teachers' Institute of Engineering and Technology,Changchun 130052,China)
关键词:
silkworm pupa protein;polypeptides;anti-tumor
摘  要:
According to the results of this study,the inhibition effects of silkworm pupa protein polypetides to on A549 and Ketr-3 cells proliferation are directly proportional to the polypeptides concentration in the range of 0.5 to 1.5 g/L.The polypetides cause a significant G2~M,G0~G1 phase arrest in A549 and Ketr-3 cells respectively.With the dosage of 150 to 600 mg/kg,the polypeptides inhibit sarcinoma 180 by 28.72% to 58.18% and hepatocarcinoma 22 by 27.64% to 63.88%,and significantly prolong the life span of the EAC-bearing mice.As a conclusion,the silkworm supa protein polypeptides has significant anti-tumor effects.

相似文章

计量
文章访问数: 14
HTML全文浏览量: 0
PDF下载量: 0

所属期刊

推荐期刊