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当前位置: 首页 > 文章 > 黄体酮聚乳酸微球制备及其体外释药特性研究 中国畜牧兽医 2011,38 (10) 230-233
Position: Home > Articles > Preparation and in vitro Release Property of Polylactic Acid Microspheres Containing Progesterone China Animal Husbandry & Veterinary Medicine 2011,38 (10) 230-233

黄体酮聚乳酸微球制备及其体外释药特性研究

作  者：
高豪;方炳虎;刘雅红;陈朝喜;唐咏泳;陈建新
单  位：
华南农业大学兽医学院广东省兽药研制与安全评价重点实验室;西南民族大学生命科学与技术学院
关键词：
黄体酮;聚乳酸微球;体外释放
摘  要：
本试验旨在制备黄体酮聚乳酸微球,并考察其体外释药性能。以包封率、载药量为主要评价指标,考察制备黄体酮微球的主要影响因素,筛选出最佳工艺条件。扫描电子显微镜观察微球形态,紫外—可见分光光度法测定微球的包封率、载药量和体外释药特性。最佳工艺所制备的微球光滑、圆整、均匀、分散性好,包封率为(80.60±1.00)%,载药量为(10.63±0.05)%,在7d内累积释药率达53.41%。制备微球包封率和载药量高,具有明显的缓释效果,能有效地延长药物作用时间。
译  名：
Preparation and in vitro Release Property of Polylactic Acid Microspheres Containing Progesterone
作  者：
GAO Hao1,FANG Bing-hu1,LIU Ya-hong1,CHEN Chao-xi2,TANG Yong-yong1,CHEN Jian-xin1(1.College of Veterinary Medicine,Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation,South China Agricultural University,Guangzhou 510642,China; 2.Department of Life Science and Technology,Southwest University for Nationalities,Chengdu 610041,China)
关键词：
progesterone;polylactic acid microspheres;in vitro release
摘  要：
To prepare progesterone PLA microspheres by emulsification solvent evaporation process and investigate the characteristics of progesterone PLA microspheres in vitro release.Progesterone PLA microspheres formulation and preparation parameters were investigated and established basing on the entrapment efficiency and content of the drug.Seven factors were selected to establish the optimal conditions.The morphology of microspheres was characterized by SEM.UV spectrometry was used to determine the entrapment efficiency,the drug loading and release property in vitro.The progesterone PLA microspheres were smooth,round,well dispersed and consistent diameters.The entrapment efficiency of the progesterone PLA microspheres was(80.60±1.00)%,drug loading was(10.63±0.05)%,cumulative release in 7 days was 53.41% in vitro.The progesterone PLA microspheres had distinct slow-release effect and could prolong the medicine action time.

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