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当前位置: 首页 > 文章 > 甘草素在翘嘴鳜细菌性败血症疫苗中的佐剂效果(英文) 华中农业大学学报 2000,19 (3) 256-260
Position: Home > Articles > Adjuvant Effect of Glycyrrhizine in Vaccines against Bacterial Septicemia in Mandarinfish, Siniperca chuatsi Basilewsky Journal of Huazhong Agricultural University 2000,19 (3) 256-260

甘草素在翘嘴鳜细菌性败血症疫苗中的佐剂效果(英文)

作  者：
陈昌福;陈晓辉;楠田理一
单  位：
华中农业大学水产学院!武汉430070,中国,高知大学农学部生物资源科学科!高知7838502,日本,福山大学工学部海洋生物工学科!广岛7290292,日本;华中农业大学水产学院
关键词：
甘草素;疫苗;细菌性败血症;翘嘴鳜
摘  要：
从甘草中提取的甘草素 (Gly)添加在翘嘴鳜细菌性败血症的 2种疫苗 ,即福尔马林灭活嗜水气单胞菌 (FKC)和菌体脂多糖 (LPS)中 ,经添加Gly的疫苗接种后 ,受免翘嘴鳜头肾中白细胞的吞噬活性和经活菌攻毒后的免疫保护率显著高于未添加Gly疫苗的免疫组 (t测验 ,P <0 .0 5) ,表明了Gly具有佐剂效果 ,但是受免鱼的凝集抗体效价和补体活性在全部受免鱼中则没有明显差别 (t测验 ,P >0 .0 5)
译  名：
Adjuvant Effect of Glycyrrhizine in Vaccines against Bacterial Septicemia in Mandarinfish, Siniperca chuatsi Basilewsky
作  者：
Chen Changfu 1) Chen Xiaohui 2) Riichi Kusuda 3) ( 1) Huazhong Agricultural University, Wuhan 430070, China 2) Faculty of Agriculture, Kochi University, Kochi 783?8502, Japan; 3) Fukuyama University, Hiroshima 729?0292
关键词：
glycyrrhizine, vaccine, bacterial septicemia, Siniperca chuatsi
摘  要：
The effect of glycyrrhizine (Gly) from licorice( Glycyrrhiza glabra ) as a adjuvant in vaccines against bacterial septicemia in mandarinfish( Siniperca chuatsi Basilewsky) was studied. Mandarinfish were vaccinated with formalin killed cells (FKC) and lipopolysaccharide (LPS) of Aeromonas hydrophila by injection method with or without Gly. The results showed that the phagocytic activity of leucocytes and relative percent survival (RPS) after challenge with live bacteria in vaccinated groups with Gly were significantly higher than that in groups without Gly, but after vaccination no significant differences were detected in agglutinating antibody titers and complement activity between vaccinated groups with Gly and without Gly.

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